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Items: 1 to 20 of 118


The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions.

Vázquez-Borrego MC, Fuentes-Fayos AC, Gahete MD, Castaño JP, Kineman RD, Luque RM.

Cell Physiol Biochem. 2018 Sep 11;49(4):1444-1459. doi: 10.1159/000493448. [Epub ahead of print]


40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1/IGF1R in regulating metabolism using the Cre/loxP system.

Kineman RD, Del Rio-Moreno M, Sarmento-Cabral A.

J Mol Endocrinol. 2018 Jul;61(1):T187-T198. doi: 10.1530/JME-18-0076. Epub 2018 May 9. Review.


Neuronostatin exerts actions on pituitary that are unique from its sibling peptide somatostatin.

Luque RM, Kineman RD.

J Endocrinol. 2018 Jun;237(3):217-227. doi: 10.1530/JOE-18-0135. Epub 2018 Apr 3.


Somatotroph-Specific Aip-Deficient Mice Display Pretumorigenic Alterations in Cell-Cycle Signaling.

Gillam MP, Ku CR, Lee YJ, Kim J, Kim SH, Lee SJ, Hwang B, Koo J, Kineman RD, Kiyokawa H, Lee EJ.

J Endocr Soc. 2017 Jan 13;1(2):78-95. doi: 10.1210/js.2016-1004. eCollection 2017 Feb 1.


Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

Vázquez-Borrego MC, Gahete MD, Martínez-Fuentes AJ, Fuentes-Fayos AC, Castaño JP, Kineman RD, Luque RM.

Mol Cell Endocrinol. 2018 Mar 5;463:4-22. doi: 10.1016/j.mce.2017.12.007. Epub 2017 Dec 16. Review.


Adipokines (Leptin, Adiponectin, Resistin) Differentially Regulate All Hormonal Cell Types in Primary Anterior Pituitary Cell Cultures from Two Primate Species.

Sarmento-Cabral A, Peinado JR, Halliday LC, Malagon MM, Castaño JP, Kineman RD, Luque RM.

Sci Rep. 2017 Mar 6;7:43537. doi: 10.1038/srep43537.


BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.

Ibáñez-Costa A, López-Sánchez LM, Gahete MD, Rivero-Cortés E, Vázquez-Borrego MC, Gálvez MA, de la Riva A, Venegas-Moreno E, Jiménez-Reina L, Moreno-Carazo A, Tinahones FJ, Maraver-Selfa S, Japón MA, García-Arnés JA, Soto-Moreno A, Webb SM, Kineman RD, Culler MD, Castaño JP, Luque RM.

Sci Rep. 2017 Feb 9;7:42002. doi: 10.1038/srep42002.


Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice.

Wolf Greenstein A, Majumdar N, Yang P, Subbaiah PV, Kineman RD, Cordoba-Chacon J.

J Endocrinol. 2017 Jan;232(1):107-121. Epub 2016 Oct 31.


Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.


Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice.

Kineman RD, Majumdar N, Subbaiah PV, Cordoba-Chacon J.

Endocrinology. 2016 May;157(5):1728-35. doi: 10.1210/en.2015-2077. Epub 2016 Mar 7.


Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.

Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.


Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

Cordoba-Chacon J, Majumdar N, Pokala NK, Gahete MD, Kineman RD.

Growth Horm IGF Res. 2015 Aug;25(4):189-95. doi: 10.1016/j.ghir.2015.04.002. Epub 2015 Apr 17.


Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas.

Luque RM, Ibáñez-Costa A, Neto LV, Taboada GF, Hormaechea-Agulla D, Kasuki L, Venegas-Moreno E, Moreno-Carazo A, Gálvez MÁ, Soto-Moreno A, Kineman RD, Culler MD, Gahete MD, Gadelha MR, Castaño JP.

Cancer Lett. 2015 Apr 10;359(2):299-306. doi: 10.1016/j.canlet.2015.01.037. Epub 2015 Jan 28.


Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates.

Ibáñez-Costa A, Córdoba-Chacón J, Gahete MD, Kineman RD, Castaño JP, Luque RM.

Endocrinology. 2015 Mar;156(3):1100-10. doi: 10.1210/en.2014-1819. Epub 2014 Dec 29.


Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Cordoba-Chacon J, Gahete MD, McGuinness OP, Kineman RD.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.


Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice.

Gahete MD, Córdoba-Chacón J, Lantvit DD, Ortega-Salas R, Sanchez-Sanchez R, Pérez-Jiménez F, López-Miranda J, Swanson SM, Castaño JP, Luque RM, Kineman RD.

Carcinogenesis. 2014 Nov;35(11):2467-73. doi: 10.1093/carcin/bgu161. Epub 2014 Aug 1.


Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Luque RM, Córdoba-Chacón J, Ibáñez-Costa A, Gesmundo I, Grande C, Gracia-Navarro F, Tena-Sempere M, Ghigo E, Gahete MD, Granata R, Kineman RD, Castaño JP.

Endocrinology. 2014 Apr;155(4):1407-17. doi: 10.1210/en.2013-1728. Epub 2014 Jan 31.


Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

Cordoba-Chacon J, Gahete MD, Pokala NK, Geldermann D, Alba M, Salvatori R, Luque RM, Kineman RD.

Endocrinology. 2014 Mar;155(3):726-35. doi: 10.1210/en.2013-1825. Epub 2013 Dec 16.


Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Kineman RD, Luque RM.

Endocrinology. 2013 Jul;154(7):2393-8. doi: 10.1210/en.2013-1136. Epub 2013 May 21.


Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Gahete MD, Córdoba-Chacón J, Lin Q, Brüning JC, Kahn CR, Castaño JP, Christian H, Luque RM, Kineman RD.

Endocrinology. 2013 Jul;154(7):2410-20. doi: 10.1210/en.2013-1261. Epub 2013 May 13.

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