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Items: 19

1.

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097.

2.

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.

Ruderfer DM, Charney AW, Readhead B, Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, Sklar P.

Lancet Psychiatry. 2016 Apr;3(4):350-7. doi: 10.1016/S2215-0366(15)00553-2.

PMID:
26915512
3.

Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.

McCarroll MN, Gendelev L, Keiser MJ, Kokel D.

ACS Chem Biol. 2016 Apr 15;11(4):842-9. doi: 10.1021/acschembio.5b00800.

4.

Prediction and validation of enzyme and transporter off-targets for metformin.

Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):463-75. doi: 10.1007/s10928-015-9436-y.

5.

Systems pharmacology augments drug safety surveillance.

Lorberbaum T, Nasir M, Keiser MJ, Vilar S, Hripcsak G, Tatonetti NP.

Clin Pharmacol Ther. 2015 Feb;97(2):151-8. doi: 10.1002/cpt.2.

6.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K.

PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712.

7.

Large-scale prediction and testing of drug activity on side-effect targets.

Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L.

Nature. 2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159.

8.

Chemical informatics and target identification in a zebrafish phenotypic screen.

Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL Jr, Roth BL, Peterson RT, Shoichet BK.

Nat Chem Biol. 2011 Dec 18;8(2):144-6. doi: 10.1038/nchembio.732.

9.

The chemical basis of pharmacology.

Keiser MJ, Irwin JJ, Shoichet BK.

Biochemistry. 2010 Dec 7;49(48):10267-76. doi: 10.1021/bi101540g. Review.

10.

The presynaptic component of the serotonergic system is required for clozapine's efficacy.

Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL.

Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195.

12.

Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.

Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK.

J Med Chem. 2010 Jul 8;53(13):4891-905. doi: 10.1021/jm100488w.

13.

Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

DeGraw AJ, Keiser MJ, Ochocki JD, Shoichet BK, Distefano MD.

J Med Chem. 2010 Mar 25;53(6):2464-71. doi: 10.1021/jm901613f.

14.

Predicting new molecular targets for known drugs.

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL.

Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506.

15.

Off-target networks derived from ligand set similarity.

Keiser MJ, Hert J.

Methods Mol Biol. 2009;575:195-205. doi: 10.1007/978-1-60761-274-2_8.

PMID:
19727616
16.

A mapping of drug space from the viewpoint of small molecule metabolism.

Adams JC, Keiser MJ, Basuino L, Chambers HF, Lee DS, Wiest OG, Babbitt PC.

PLoS Comput Biol. 2009 Aug;5(8):e1000474. doi: 10.1371/journal.pcbi.1000474.

17.

Quantifying biogenic bias in screening libraries.

Hert J, Irwin JJ, Laggner C, Keiser MJ, Shoichet BK.

Nat Chem Biol. 2009 Jul;5(7):479-83. doi: 10.1038/nchembio.180.

18.

Quantifying the relationships among drug classes.

Hert J, Keiser MJ, Irwin JJ, Oprea TI, Shoichet BK.

J Chem Inf Model. 2008 Apr;48(4):755-65. doi: 10.1021/ci8000259.

19.

Relating protein pharmacology by ligand chemistry.

Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK.

Nat Biotechnol. 2007 Feb;25(2):197-206.

PMID:
17287757
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