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Items: 1 to 20 of 99


Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.

Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM.

Cell. 2018 Oct 18;175(3):822-834.e18. doi: 10.1016/j.cell.2018.09.015. Epub 2018 Oct 11.


Human β-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.

Ti SC, Alushin GM, Kapoor TM.

Dev Cell. 2018 Oct 22;47(2):175-190.e5. doi: 10.1016/j.devcel.2018.08.014. Epub 2018 Sep 20.


Analyzing the micromechanics of the cell division apparatus.

Shimamoto Y, Kapoor TM.

Methods Cell Biol. 2018;145:173-190. doi: 10.1016/bs.mcb.2018.03.022. Epub 2018 May 1.


A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Kleiner RE, Hang LE, Molloy KR, Chait BT, Kapoor TM.

Cell Chem Biol. 2018 Jan 18;25(1):110-120.e3. doi: 10.1016/j.chembiol.2017.10.001. Epub 2017 Nov 5.


Leveraging Chemotype-Specific Resistance for Drug Target Identification and Chemical Biology.

Kapoor TM, Miller RM.

Trends Pharmacol Sci. 2017 Dec;38(12):1100-1109. doi: 10.1016/ Epub 2017 Oct 13. Review.


Comparison of the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus to More Complex Disease Activity Instruments As Evaluated by Clinical Investigators or Real-World Clinicians.

Askanase AD, Nguyen SC, Costenbader K, Lim SS, Kamen D, Aranow C, Grossman J, Kapoor TM, Baker-Frost D, Aberle T, Thanou-Stavraki A, Hanrahan LM, Kim M, Merrill JT.

Arthritis Care Res (Hoboken). 2018 Jul;70(7):1058-1063. doi: 10.1002/acr.23445. Epub 2018 May 21.


Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.

Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM.

Elife. 2017 May 19;6. pii: e25174. doi: 10.7554/eLife.25174.


The mechanics of microtubule networks in cell division.

Forth S, Kapoor TM.

J Cell Biol. 2017 Jun 5;216(6):1525-1531. doi: 10.1083/jcb.201612064. Epub 2017 May 10. Review.


Low prevalence of Pneumocystis pneumonia in hospitalized patients with systemic lupus erythematosus: review of a clinical data warehouse.

Kapoor TM, Mahadeshwar P, Nguyen S, Li J, Kapoor S, Bathon J, Giles J, Askanase A.

Lupus. 2017 Dec;26(14):1473-1482. doi: 10.1177/0961203317703494. Epub 2017 Apr 11.


Metaphase Spindle Assembly.

Kapoor TM.

Biology (Basel). 2017 Feb 3;6(1). pii: E8. doi: 10.3390/biology6010008. Review.


Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis.

Kawashima SA, Chen Z, Aoi Y, Patgiri A, Kobayashi Y, Nurse P, Kapoor TM.

Cell. 2016 Oct 6;167(2):512-524.e14. doi: 10.1016/j.cell.2016.08.070. Epub 2016 Sep 22.


Near-atomic cryo-EM structure of PRC1 bound to the microtubule.

Kellogg EH, Howes S, Ti SC, Ramírez-Aportela E, Kapoor TM, Chacón P, Nogales E.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9430-9. doi: 10.1073/pnas.1609903113. Epub 2016 Aug 4.


The structured core of human β tubulin confers isotype-specific polymerization properties.

Pamula MC, Ti SC, Kapoor TM.

J Cell Biol. 2016 May 23;213(4):425-33. doi: 10.1083/jcb.201603050. Epub 2016 May 16.


Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.

Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM.

Dev Cell. 2016 Apr 4;37(1):72-84. doi: 10.1016/j.devcel.2016.03.003.


Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.

See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK.

ACS Chem Biol. 2016 Jan 15;11(1):53-60. doi: 10.1021/acschembio.5b00895. Epub 2015 Nov 11.


Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules.

Shimamoto Y, Forth S, Kapoor TM.

Dev Cell. 2015 Sep 28;34(6):669-81. doi: 10.1016/j.devcel.2015.08.017.


Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Kleiner RE, Verma P, Molloy KR, Chait BT, Kapoor TM.

Nat Chem Biol. 2015 Oct;11(10):807-14. doi: 10.1038/nchembio.1908. Epub 2015 Sep 7.


Reconstitution of the augmin complex provides insights into its architecture and function.

Hsia KC, Wilson-Kubalek EM, Dottore A, Hao Q, Tsai KL, Forth S, Shimamoto Y, Milligan RA, Kapoor TM.

Nat Cell Biol. 2014 Sep;16(9):852-63. doi: 10.1038/ncb3030. Epub 2014 Aug 31.


Direct kinetochore-spindle pole connections are not required for chromosome segregation.

Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A.

J Cell Biol. 2014 Jul 21;206(2):231-43. doi: 10.1083/jcb.201401090. Epub 2014 Jul 14.


The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.

He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV.

Nat Cell Biol. 2014 Jul;16(7):663-72. doi: 10.1038/ncb2988. Epub 2014 Jun 22.

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