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Items: 1 to 20 of 292

1.

The SIAH1-HIPK2-p53ser46 damage response pathway is involved in temozolomide-induced glioblastoma cell death.

He Y, Roos WP, Wu Q, Hofmann TG, Kaina B.

Mol Cancer Res. 2019 Feb 22. pii: molcanres.1306.2018. doi: 10.1158/1541-7786.MCR-18-1306. [Epub ahead of print]

PMID:
30796178
2.

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Kraus A, McKeague M, Seiwert N, Nagel G, Geisen SM, Ziegler N, Trantakis IA, Kaina B, Thomas AD, Sturla SJ, Fahrer J.

Arch Toxicol. 2019 Feb;93(2):559-572. doi: 10.1007/s00204-018-2355-0. Epub 2018 Nov 16.

PMID:
30446773
3.

Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.

Laarmann K, Kress JM, Kaina B, Fritz G.

DNA Repair (Amst). 2019 Jan;73:17-27. doi: 10.1016/j.dnarep.2018.10.005. Epub 2018 Oct 28.

PMID:
30413344
4.

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB.

Aasland D, Götzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B, Christmann M.

Cancer Res. 2019 Jan 1;79(1):99-113. doi: 10.1158/0008-5472.CAN-18-1733. Epub 2018 Oct 25.

PMID:
30361254
5.
6.

Compromised DNA Repair and Signalling in Human Granulocytes.

Ponath V, Heylmann D, Haak T, Woods K, Becker H, Kaina B.

J Innate Immun. 2019;11(1):74-85. doi: 10.1159/000492678. Epub 2018 Oct 8.

7.

Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy.

Kaina B, Izzotti A, Xu J, Christmann M, Pulliero A, Zhao X, Dobreanu M, Au WW.

Int J Hyg Environ Health. 2018 Aug;221(7):993-1006. doi: 10.1016/j.ijheh.2018.07.003. Epub 2018 Jul 21. Review.

PMID:
30041861
8.

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9.

9.

The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study.

Venkatachalam S, Mettler E, Fottner C, Miederer M, Kaina B, Weber MM.

Clin Transl Radiat Oncol. 2017 Oct 5;7:1-8. doi: 10.1016/j.ctro.2017.09.006. eCollection 2017 Dec.

10.

XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair.

Roos WP, Frohnapfel L, Quiros S, Ringel F, Kaina B.

Cancer Lett. 2018 Jun 28;424:119-126. doi: 10.1016/j.canlet.2018.03.025. Epub 2018 Mar 22.

PMID:
29574277
11.

Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation.

Aasland D, Reich TR, Tomicic MT, Switzeny OJ, Kaina B, Christmann M.

J Neurochem. 2018 Jan;144(2):139-151. doi: 10.1111/jnc.14262. Epub 2018 Jan 1.

12.

Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases.

Tomaszowski KH, Hellmann N, Ponath V, Takatsu H, Shin HW, Kaina B.

Sci Rep. 2017 Oct 24;7(1):13925. doi: 10.1038/s41598-017-14129-x.

13.

Genotoxicity testing: Comparison of the γH2AX focus assay with the alkaline and neutral comet assays.

Nikolova T, Marini F, Kaina B.

Mutat Res. 2017 Oct;822:10-18. doi: 10.1016/j.mrgentox.2017.07.004. Epub 2017 Jul 22.

PMID:
28844237
14.

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells.

Seiwert N, Neitzel C, Stroh S, Frisan T, Audebert M, Toulany M, Kaina B, Fahrer J.

Cell Death Dis. 2017 Aug 24;8(8):e3019. doi: 10.1038/cddis.2017.418.

15.

Is there a Genotoxic Potential of Endodontic Root Materials?

Taubmann A, Willershausen B, Erbe C, Kaina B, Willershausen I.

Clin Lab. 2017 Apr 1;63(4):689-697. doi: 10.7754/Clin.Lab.2016.161102.

PMID:
28397460
16.

DNA damage in lymphocytes of patients suffering from complex traumatization.

Bergholz LM, Subic-Wrana C, Heylmann D, Beutel ME, Wiltink J, Kaina B.

DNA Repair (Amst). 2017 Apr;52:103-109. doi: 10.1016/j.dnarep.2017.02.006. Epub 2017 Feb 9.

PMID:
28254426
17.

Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

Nikolova T, Roos WP, Krämer OH, Strik HM, Kaina B.

Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):29-39. doi: 10.1016/j.bbcan.2017.01.004. Epub 2017 Jan 29. Review.

PMID:
28143714
18.

Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome.

Reich TR, Switzeny OJ, Renovanz M, Sommer C, Kaina B, Christmann M, Tomicic MT.

Oncotarget. 2017 Feb 28;8(9):15071-15084. doi: 10.18632/oncotarget.14748.

19.

Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans.

Ponath V, Kaina B.

PLoS One. 2017 Jan 18;12(1):e0170347. doi: 10.1371/journal.pone.0170347. eCollection 2017.

20.

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.

Noack K, Mahendrarajah N, Hennig D, Schmidt L, Grebien F, Hildebrand D, Christmann M, Kaina B, Sellmer A, Mahboobi S, Kubatzky K, Heinzel T, Krämer OH.

Arch Toxicol. 2017 May;91(5):2191-2208. doi: 10.1007/s00204-016-1878-5. Epub 2016 Nov 2.

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