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Items: 1 to 20 of 441

1.

The proton electrochemical gradient induces a kinetic asymmetry in the symport cycle of LacY.

Jiang X, Ermolova N, Lim J, Choi SW, Kaback HR.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):977-981. doi: 10.1073/pnas.1916563117. Epub 2019 Dec 30.

2.

It takes two to tango: The dance of the permease.

Kaback HR, Guan L.

J Gen Physiol. 2019 Jul 1;151(7):878-886. doi: 10.1085/jgp.201912377. Epub 2019 May 30. Review.

3.

Insertion and folding pathways of single membrane proteins guided by translocases and insertases.

Serdiuk T, Steudle A, Mari SA, Manioglu S, Kaback HR, Kuhn A, Müller DJ.

Sci Adv. 2019 Jan 30;5(1):eaau6824. doi: 10.1126/sciadv.aau6824. eCollection 2019 Jan.

4.

Arg302 governs the pKa of Glu325 in LacY.

Grytsyk N, Santos Seiça AF, Sugihara J, Kaback HR, Hellwig P.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4934-4939. doi: 10.1073/pnas.1820744116. Epub 2019 Feb 21.

5.

Engineered occluded apo-intermediate of LacY.

Smirnova I, Kasho V, Kaback HR.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12716-12721. doi: 10.1073/pnas.1816267115. Epub 2018 Nov 26.

6.

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8769-8774. doi: 10.1073/pnas.1801774115. Epub 2018 Aug 14.

7.

Oversized galactosides as a probe for conformational dynamics in LacY.

Smirnova I, Kasho V, Jiang X, Chen HM, Withers SG, Kaback HR.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4146-4151. doi: 10.1073/pnas.1800706115. Epub 2018 Mar 30.

8.

An Asymmetric Conformational Change in LacY.

Smirnova I, Kasho V, Jiang X, Kaback HR.

Biochemistry. 2017 Apr 4;56(13):1943-1950. doi: 10.1021/acs.biochem.7b00134. Epub 2017 Mar 23.

9.

Quantification of Detergents Complexed with Membrane Proteins.

Chaptal V, Delolme F, Kilburg A, Magnard S, Montigny C, Picard M, Prier C, Monticelli L, Bornert O, Agez M, Ravaud S, Orelle C, Wagner R, Jawhari A, Broutin I, Pebay-Peyroula E, Jault JM, Kaback HR, le Maire M, Falson P.

Sci Rep. 2017 Feb 8;7:41751. doi: 10.1038/srep41751.

10.

pKa of Glu325 in LacY.

Grytsyk N, Sugihara J, Kaback HR, Hellwig P.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1530-1535. doi: 10.1073/pnas.1621431114. Epub 2017 Feb 1.

11.

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.

Jiang X, Smirnova I, Kasho V, Wu J, Hirata K, Ke M, Pardon E, Steyaert J, Yan N, Kaback HR.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12420-12425. Epub 2016 Oct 19.

12.

YidC assists the stepwise and stochastic folding of membrane proteins.

Serdiuk T, Balasubramaniam D, Sugihara J, Mari SA, Kaback HR, Müller DJ.

Nat Chem Biol. 2016 Nov;12(11):911-917. doi: 10.1038/nchembio.2169. Epub 2016 Sep 5.

13.

Thermodynamics of Nanobody Binding to Lactose Permease.

Hariharan P, Andersson M, Jiang X, Pardon E, Steyaert J, Kaback HR, Guan L.

Biochemistry. 2016 Oct 25;55(42):5917-5926. doi: 10.1021/acs.biochem.6b00826. Epub 2016 Oct 12.

14.

Role of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY.

Jiang X, Andersson M, Chau BT, Wong LY, Villafuerte MK, Kaback HR.

Biochemistry. 2016 Aug 9;55(31):4326-32. doi: 10.1021/acs.biochem.6b00666. Epub 2016 Aug 1.

15.

pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases.

Bazzone A, Madej MG, Kaback HR, Fendler K.

PLoS One. 2016 May 26;11(5):e0156392. doi: 10.1371/journal.pone.0156392. eCollection 2016.

16.

Transient conformers of LacY are trapped by nanobodies.

Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13839-44. doi: 10.1073/pnas.1519485112. Epub 2015 Oct 28. Erratum in: Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E101.

17.

Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site.

Kumar H, Finer-Moore JS, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9004-9. doi: 10.1073/pnas.1509854112. Epub 2015 Jul 8.

18.

Observing a lipid-dependent alteration in single lactose permeases.

Serdiuk T, Sugihara J, Mari SA, Kaback HR, Müller DJ.

Structure. 2015 Apr 7;23(4):754-61. doi: 10.1016/j.str.2015.02.009. Epub 2015 Mar 19.

19.

Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc.

Hariharan P, Balasubramaniam D, Peterkofsky A, Kaback HR, Guan L.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2407-12. doi: 10.1073/pnas.1500891112. Epub 2015 Feb 9.

20.

A chemiosmotic mechanism of symport.

Kaback HR.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1259-64. doi: 10.1073/pnas.1419325112. Epub 2015 Jan 7.

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