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Items: 1 to 20 of 91

1.

Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.

Remy J, Linder B, Weirauch U, Konovalova J, Marschalek R, Aigner A, Kögel D.

Biochim Biophys Acta Mol Cell Res. 2018 Oct 30;1866(2):175-189. doi: 10.1016/j.bbamcr.2018.10.017. [Epub ahead of print]

PMID:
30389373
2.

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells.

Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kögel D, Fulda S.

Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1.

3.

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D.

Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21.

PMID:
29938581
4.

Pro-survival autophagy and cancer cell resistance to therapy.

Das CK, Mandal M, Kögel D.

Cancer Metastasis Rev. 2018 Mar 13. doi: 10.1007/s10555-018-9727-z. [Epub ahead of print] Review.

PMID:
29536228
5.

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells.

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D.

Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22.

6.

Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?

Aigner A, Kögel D.

Nanomedicine (Lond). 2018 Jan;13(1):89-103. doi: 10.2217/nnm-2017-0230. Epub 2017 Dec 4. Review.

PMID:
29199893
7.

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM.

Sci Rep. 2017 Aug 7;7(1):7425. doi: 10.1038/s41598-017-07631-9.

8.

A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction.

Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD.

Mech Ageing Dev. 2018 Mar;170:45-58. doi: 10.1016/j.mad.2017.06.004. Epub 2017 Jul 3.

PMID:
28684269
9.

A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover.

Pampaloni F, Mayer B, Kabat Vel-Job K, Ansari N, Hötte K, Kögel D, Stelzer EHK.

SLAS Discov. 2017 Jun;22(5):558-570. doi: 10.1177/2472555217696798. Epub 2017 Mar 15.

PMID:
28297606
10.

Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.

Copenhaver PF, Kögel D.

Front Mol Neurosci. 2017 Jan 31;10:3. doi: 10.3389/fnmol.2017.00003. eCollection 2017. Review.

11.

Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D.

Mol Neurobiol. 2016 Nov;53(9):5985-5994. doi: 10.1007/s12035-015-9501-y. Epub 2015 Nov 2.

PMID:
26526841
12.

Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.

Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D.

Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24.

13.

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M.

Oncotarget. 2016 Apr 12;7(15):20016-32. doi: 10.18632/oncotarget.7910.

14.

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D.

Biochim Biophys Acta. 2016 Apr;1863(4):499-509. doi: 10.1016/j.bbamcr.2015.12.016. Epub 2015 Dec 22.

15.

Autophagy-associated proteins BAG3 and p62 in testicular cancer.

Bartsch G, Jennewein L, Harter PN, Antonietti P, Blaheta RA, Kvasnicka HM, Kögel D, Haferkamp A, Mittelbronn M, Mani J.

Oncol Rep. 2016 Mar;35(3):1629-35. doi: 10.3892/or.2015.4505. Epub 2015 Dec 22.

PMID:
26707573
16.

Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant.

Zakaria Z, Tivnan A, Flanagan L, Murray DW, Salvucci M, Stringer BW, Day BW, Boyd AW, Kögel D, Rehm M, O'Brien DF, Byrne AT, Prehn JH.

Br J Cancer. 2016 Jan 19;114(2):188-98. doi: 10.1038/bjc.2015.420. Epub 2015 Dec 10.

17.

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner.

Kiprianova I, Remy J, Milosch N, Mohrenz IV, Seifert V, Aigner A, Kögel D.

Neoplasia. 2015 Jul;17(7):564-73. doi: 10.1016/j.neo.2015.07.003.

18.

Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T.

Cell Death Dis. 2015 Jul 9;6:e1812. doi: 10.1038/cddis.2015.181.

19.

Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme.

Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH.

Front Neurosci. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218. eCollection 2015.

20.

Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737.

Mani J, Antonietti P, Rakel S, Blaheta R, Bartsch G, Haferkamp A, Kögel D.

World J Urol. 2016 Feb;34(2):197-205. doi: 10.1007/s00345-015-1616-2. Epub 2015 Jun 23.

PMID:
26100943

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