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Items: 1 to 20 of 35

1.

A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.

Greco MN, Connelly MA, Leo GC, Olson MW, Powell E, Huang Z, Hawkins M, Smith C, Schalk-Hihi C, Darrow AL, Xin H, Lang W, Damiano BP, Hlasta DJ.

Bioorg Med Chem Lett. 2013 May 1;23(9):2595-7. doi: 10.1016/j.bmcl.2013.02.113. Epub 2013 Mar 7.

PMID:
23528297
2.

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.

Matthews JM, Chen X, Cryan E, Hlasta DJ, Rybczynski PJ, Strauss K, Tang Y, Xu JZ, Yang M, Zhou L, Demarest KT.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6773-8. Epub 2007 Oct 17.

PMID:
18029176
3.

Cycloaddition reactions of thiazolium azomethine ylides: application to pyrrolo[2,1-b]thiazoles.

Berry CR, Zificsak CA, Gibbs AC, Hlasta DJ.

Org Lett. 2007 Oct 11;9(21):4099-102. Epub 2007 Sep 14.

PMID:
17854191
4.

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.

Paget SD, Boggs CM, Foleno BD, Goldschmidt RM, Hlasta DJ, Weidner-Wells MA, Werblood HM, Bush K, Macielag MJ.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4537-42. Epub 2006 Jun 27.

PMID:
16806921
5.

Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.

Gong Y, Barbay JK, Dyatkin AB, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Ballentine SA, Hageman WE, Masucci JA, Maryanoff BE, Damiano BP, Andrade-Gordon P, Hlasta DJ, Hornby PJ, He W.

J Med Chem. 2006 Jun 1;49(11):3402-11.

PMID:
16722660
6.

Trimethylsilyl-directed 1,3-dipolar cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles.

Coats SJ, Link JS, Gauthier D, Hlasta DJ.

Org Lett. 2005 Apr 14;7(8):1469-72.

PMID:
15816729
7.

Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.

Coats SJ, Schulz MJ, Carson JR, Codd EE, Hlasta DJ, Pitis PM, Stone DJ Jr, Zhang SP, Colburn RW, Dax SL.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5493-8.

PMID:
15482911
8.

Method for the parallel preparation of the aspartic protease isostere: hydroxyethylamino amides.

Coats SJ, Schulz MJ, Hlasta DJ.

J Comb Chem. 2004 Sep-Oct;6(5):688-91. No abstract available.

PMID:
15360200
9.

Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics.

Henninger TC, Xu X, Abbanat D, Baum EZ, Foleno BD, Hilliard JJ, Bush K, Hlasta DJ, Macielag MJ.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4495-9.

PMID:
15357979
10.

Microwave-assisted preparation of aryltetrazoleboronate esters.

Schulz MJ, Coats SJ, Hlasta DJ.

Org Lett. 2004 Sep 16;6(19):3265-8.

PMID:
15355028
11.

Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists.

Weidner-Wells MA, Henninger TC, Fraga-Spano SA, Boggs CM, Matheis M, Ritchie DM, Argentieri DC, Wachter MP, Hlasta DJ.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4307-11.

PMID:
15261292
12.

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.

Matthews JM, Hoekstra WJ, Dyatkin AB, Hecker LR, Hlasta DJ, Poulter BL, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Reynolds CH, Maryanoff BE.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2747-52.

PMID:
15125926
13.

Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.

Dyatkin AB, Hoekstra WJ, Kinney WA, Kontoyianni M, Santulli RJ, Kimball ES, Fisher MC, Prouty SM, Abraham WM, de Garavilla L, Andrade-Gordon P, Hlasta DJ, He W, Hornby PJ, Damiano BP, Maryanoff BE.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):591-6. Erratum in: Bioorg Med Chem Lett. 2004 May 3;14(9):2371.

PMID:
14741249
14.

Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones.

Paget SD, Foleno BD, Boggs CM, Goldschmidt RM, Hlasta DJ, Weidner-Wells MA, Werblood HM, Wira E, Bush K, Macielag MJ.

Bioorg Med Chem Lett. 2003 Dec 1;13(23):4173-7.

PMID:
14622996
15.

Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.

Lee J, Reynolds C, Jetter MC, Youngman MA, Hlasta DJ, Dax SL, Stone DJ, Zhang SP, Codd EE.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1879-82.

PMID:
12749889
16.
17.
18.

Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity.

Dyatkin AB, Hoekstra WJ, Hlasta DJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Gunnet JW, Hageman W, Look R, Maryanoff BE.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3081-4. Erratum in: Bioorg Med Chem Lett. 2004 Jun 21;14(12):3363.

PMID:
12372506
19.

Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-Substituent.

Weidner-Wells MA, Boggs CM, Foleno BD, Melton J, Bush K, Goldschmidt RM, Hlasta DJ.

Bioorg Med Chem. 2002 Jul;10(7):2345-51.

PMID:
11983532
20.

Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists.

Grant EB, Guiadeen D, Singer M, Argentieri D, Hlasta DJ, Wachter M.

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2817-20.

PMID:
11597407

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