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Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Flaherty K, Duley L, England TJ, Havard D, Heptinstall S, James M, Kasonde C, Krishnan K, Markus HS, Montgomery AA, Pocock S, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N.

Health Technol Assess. 2018 Aug;22(48):1-76. doi: 10.3310/hta22480.


Platelet aggregation measured by single-platelet counting and using PFA-100 devices.

Dovlatova N, Heptinstall S.

Platelets. 2018 Nov;29(7):656-661. doi: 10.1080/09537104.2018.1492109. Epub 2018 Jul 9. Review.


Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders.

Bath PM, May J, Heptinstall S.

Platelets. 2018 Jul;29(5):425-430. doi: 10.1080/09537104.2018.1445839. Epub 2018 Apr 18. Review.


How does measurement of platelet P-selectin compare with other methods of measuring platelet function as a means of determining the effectiveness of antiplatelet therapy?

Fox SC, May JA, Dovlatova N, Glenn JR, Johnson A, White AE, Radhakrishnan A, Heptinstall S.

Platelets. 2018 Feb 20:1-6. doi: 10.1080/09537104.2018.1434311. [Epub ahead of print]


Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; TARDIS Investigators.

Lancet. 2018 Mar 3;391(10123):850-859. doi: 10.1016/S0140-6736(17)32849-0. Epub 2017 Dec 20.


UDP-sugars activate P2Y14 receptors to mediate vasoconstriction of the porcine coronary artery.

Abbas ZSB, Latif ML, Dovlatova N, Fox SC, Heptinstall S, Dunn WR, Ralevic V.

Vascul Pharmacol. 2018 Apr;103-105:36-46. doi: 10.1016/j.vph.2017.12.063. Epub 2017 Dec 15.


A Remote Assay for Measuring Canine Platelet Activation and the Inhibitory Effects of Antiplatelet Agents.

Dunning M, May J, Adamany J, Heptinstall S, Fox S.

J Vet Intern Med. 2018 Jan;32(1):119-127. doi: 10.1111/jvim.14845. Epub 2017 Dec 2.


Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack.

Bath PM, May J, Flaherty K, Woodhouse LJ, Dovlatova N, Fox SC, England TJ, Krishnan K, Robinson TG, Sprigg N, Heptinstall S, Investigators T.

Stroke Res Treat. 2017;2017:7365684. doi: 10.1155/2017/7365684. Epub 2017 May 24.


James G. White MD, 1929-2016.

Heptinstall S.

Platelets. 2017 Jan;28(1):103-105. doi: 10.1080/09537104.2016.1274617. Epub 2016 Dec 29. No abstract available.


Novel strategies for assessing platelet reactivity.

Algahtani M, Heptinstall S.

Future Cardiol. 2017 Jan;13(1):33-47. doi: 10.2217/fca-2016-0054. Epub 2016 Dec 19. Review.


Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial.

Bath PM, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Heptinstall S, James M, Krishnan K, Markus HS, Pocock S, Ranta A, Robinson TG, Flaherty K, Scutt P, Venables GS, Woodhouse LJ, Sprigg N.

Int J Stroke. 2017 Jul;12(5):524-538. doi: 10.1177/1747493016677988. Epub 2016 Nov 4.


A story of cooperation and friendship in Europe with good outcomes.

Heptinstall S.

Platelets. 2016 Sep;27(6):495. doi: 10.1080/09537104.2016.1213556. Epub 2016 Jul 26. No abstract available.


Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388).

TARDIS Trial Investigators, Krishnan K, Beridze M, Christensen H, Dineen R, Duley L, Heptinstall S, James M, Markus HS, Pocock S, Ranta A, Robinson T, Nikola N, Venables G, Bath P.

Int J Stroke. 2015 Oct;10(7):1159-65. doi: 10.1111/ijs.12538. Epub 2015 Jun 16.


An observational study investigating the effect of platelet function on outcome after colorectal surgery.

Keeler BD, Simpson JA, Fox SC, Stavrou CL, Briggs RA, Patel P, Heptinstall S, Acheson AG.

Int J Surg. 2015 May;17:28-33. doi: 10.1016/j.ijsu.2015.02.023. Epub 2015 Mar 7.


Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders.

Dovlatova N, Lordkipanidzé M, Lowe GC, Dawood B, May J, Heptinstall S, Watson SP, Fox SC; UK GAPP Study Group.

J Thromb Haemost. 2014 May;12(5):660-5. doi: 10.1111/jth.12555.


A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel.

Thomas MR, Wijeyeratne YD, May JA, Johnson A, Heptinstall S, Fox SC.

Platelets. 2014;25(8):612-8. doi: 10.3109/09537104.2013.863858. Epub 2014 Jan 16.


'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists.

Glenn JR, Dovlatova N, White AE, Dhillon K, Heptinstall S, Fox SC.

Thromb Haemost. 2014 Mar 3;111(3):539-48. doi: 10.1160/TH13-07-0581. Epub 2013 Nov 21.


How important is it to keep taking the aspirin?

Heptinstall S.

Thromb Haemost. 2013 Dec;110(6):1108-9. doi: 10.1160/TH13-10-0886. Epub 2013 Nov 14. No abstract available.


Effects on platelet function of an EP3 receptor antagonist used alone and in combination with a P2Y12 antagonist both in-vitro and ex-vivo in human volunteers.

Fox SC, May JA, Johnson A, Hermann D, Strieter D, Hartman D, Heptinstall S.

Platelets. 2013;24(5):392-400. doi: 10.3109/09537104.2012.704648. Epub 2012 Aug 6.


Platelet activation by an extracellular adherence protein from Staphylococcus aureus acting via modulation of sulfhydryl groups on platelets.

Heptinstall S.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1751-2. doi: 10.1161/ATVBAHA.112.252460. No abstract available.


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