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Items: 1 to 20 of 76

1.

Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALS.

Nijssen J, Aguila J, Hoogstraaten R, Kee N, Hedlund E.

Stem Cell Reports. 2018 Dec 11;11(6):1565-1578. doi: 10.1016/j.stemcr.2018.11.005.

PMID:
30540963
2.

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome.

Rusch M, Nakitandwe J, Shurtleff S, Newman S, Zhang Z, Edmonson MN, Parker M, Jiao Y, Ma X, Liu Y, Gu J, Walsh MF, Becksfort J, Thrasher A, Li Y, McMurry J, Hedlund E, Patel A, Easton J, Yergeau D, Vadodaria B, Tatevossian RG, Raimondi S, Hedges D, Chen X, Hagiwara K, McGee R, Robinson GW, Klco JM, Gruber TA, Ellison DW, Downing JR, Zhang J.

Nat Commun. 2018 Sep 27;9(1):3962. doi: 10.1038/s41467-018-06485-7.

3.

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling.

Lund H, Pieber M, Parsa R, Grommisch D, Ewing E, Kular L, Han J, Zhu K, Nijssen J, Hedlund E, Needhamsen M, Ruhrmann S, Guerreiro-Cacais AO, Berglund R, Forteza MJ, Ketelhuth DFJ, Butovsky O, Jagodic M, Zhang XM, Harris RA.

Nat Immunol. 2018 May;19(5):1-7. doi: 10.1038/s41590-018-0091-5. Epub 2018 Apr 16.

PMID:
29662171
4.

CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.

Reber S, Mechtersheimer J, Nasif S, Benitez JA, Colombo M, Domanski M, Jutzi D, Hedlund E, Ruepp MD.

Mol Biol Cell. 2018 Jan 15;29(2):75-83. doi: 10.1091/mbc.E17-05-0288. Epub 2017 Nov 22.

5.

Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.

Mills R, Taylor-Weiner H, Correia JC, Agudelo LZ, Allodi I, Kolonelou C, Martinez-Redondo V, Ferreira DMS, Nichterwitz S, Comley LH, Lundin V, Hedlund E, Ruas JL, Teixeira AI.

Mol Metab. 2018 Jan;7:12-22. doi: 10.1016/j.molmet.2017.11.001. Epub 2017 Nov 7.

6.

LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.

Nichterwitz S, Benitez JA, Hoogstraaten R, Deng Q, Hedlund E.

Methods Mol Biol. 2018;1649:95-110. doi: 10.1007/978-1-4939-7213-5_6.

PMID:
29130192
7.

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons.

Pereira M, Birtele M, Shrigley S, Benitez JA, Hedlund E, Parmar M, Ottosson DR.

Stem Cell Reports. 2017 Sep 12;9(3):742-751. doi: 10.1016/j.stemcr.2017.07.023. Epub 2017 Aug 24.

8.

Single-cell RNA sequencing: Technical advancements and biological applications.

Hedlund E, Deng Q.

Mol Aspects Med. 2018 Feb;59:36-46. doi: 10.1016/j.mam.2017.07.003. Epub 2017 Aug 1. Review.

PMID:
28754496
9.

Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis.

Nijssen J, Comley LH, Hedlund E.

Acta Neuropathol. 2017 Jun;133(6):863-885. doi: 10.1007/s00401-017-1708-8. Epub 2017 Apr 13. Review.

10.

The genomic landscape of core-binding factor acute myeloid leukemias.

Faber ZJ, Chen X, Gedman AL, Boggs K, Cheng J, Ma J, Radtke I, Chao JR, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, Cai Z, Mulder H, Wu G, Edmonson M, Rusch M, Qu C, Li Y, Vadodaria B, Wang J, Hedlund E, Cao X, Yergeau D, Nakitandwe J, Pounds SB, Shurtleff S, Fulton RS, Fulton LL, Easton J, Parganas E, Pui CH, Rubnitz JE, Ding L, Mardis ER, Wilson RK, Gruber TA, Mullighan CG, Schlenk RF, Paschka P, Döhner K, Döhner H, Bullinger L, Zhang J, Klco JM, Downing JR.

Nat Genet. 2016 Dec;48(12):1551-1556. doi: 10.1038/ng.3709. Epub 2016 Oct 31.

11.

Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation.

Chen G, Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q.

Genome Res. 2016 Oct;26(10):1342-1354. Epub 2016 Aug 2.

12.

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling.

Nichterwitz S, Chen G, Aguila Benitez J, Yilmaz M, Storvall H, Cao M, Sandberg R, Deng Q, Hedlund E.

Nat Commun. 2016 Jul 8;7:12139. doi: 10.1038/ncomms12139.

13.

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A.

Sci Rep. 2016 Jun 1;6:26448. doi: 10.1038/srep26448.

14.

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.

Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez JA, Cao M, Corti S, Hedlund E.

Sci Rep. 2016 May 16;6:25960. doi: 10.1038/srep25960.

15.

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

Lewandowski SA, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, Adzemovic MZ, Nichterwitz S, Lawrence DA, Hedlund E, Eriksson U.

Acta Neuropathol. 2016 Mar;131(3):453-64. doi: 10.1007/s00401-015-1520-2. Epub 2015 Dec 19.

16.

Cross-disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology.

Comley LH, Nijssen J, Frost-Nylen J, Hedlund E.

J Comp Neurol. 2016 May 1;524(7):1424-42. doi: 10.1002/cne.23917. Epub 2015 Nov 23.

17.

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS.

Comley L, Allodi I, Nichterwitz S, Nizzardo M, Simone C, Corti S, Hedlund E.

Neuroscience. 2015 Apr 16;291:216-29. doi: 10.1016/j.neuroscience.2015.02.013. Epub 2015 Feb 16.

18.

The genomic landscape of childhood and adolescent melanoma.

Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski MA, Valentine M, Navid F, Mulder H, Tatevossian RG, Dalton J, Davenport J, Yin Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A.

J Invest Dermatol. 2015 Mar;135(3):816-823. doi: 10.1038/jid.2014.425. Epub 2014 Sep 30.

19.

Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations.

Tirode F, Surdez D, Ma X, Parker M, Le Deley MC, Bahrami A, Zhang Z, Lapouble E, Grossetête-Lalami S, Rusch M, Reynaud S, Rio-Frio T, Hedlund E, Wu G, Chen X, Pierron G, Oberlin O, Zaidi S, Lemmon G, Gupta P, Vadodaria B, Easton J, Gut M, Ding L, Mardis ER, Wilson RK, Shurtleff S, Laurence V, Michon J, Marec-Bérard P, Gut I, Downing J, Dyer M, Zhang J, Delattre O; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project and the International Cancer Genome Consortium.

Cancer Discov. 2014 Nov;4(11):1342-53. doi: 10.1158/2159-8290.CD-14-0622. Epub 2014 Sep 15.

20.

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG.

N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088.

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