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Items: 1 to 20 of 104

1.

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study.

Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM.

Rejuvenation Res. 2016 Dec;19(6):478-484. Epub 2016 Mar 30.

2.

Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study.

Dow CT, Harley CB.

Clin Ophthalmol. 2016 Jan 28;10:243-9. doi: 10.2147/OPTH.S100042. eCollection 2016.

3.

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY.

Neurosignals. 2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31.

4.

A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response.

Harley CB, Liu W, Flom PL, Raffaele JM.

Rejuvenation Res. 2013 Oct;16(5):386-95. doi: 10.1089/rej.2013.1430.

PMID:
23808324
5.

A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R.

PLoS One. 2013;8(3):e58423. doi: 10.1371/journal.pone.0058423. Epub 2013 Mar 14.

6.

Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.

Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH.

Planta Med. 2012 Jan;78(2):115-21. doi: 10.1055/s-0031-1280346. Epub 2011 Nov 14.

PMID:
22083896
7.

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.

Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA.

Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700.x. Epub 2011 Apr 14.

8.

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition.

Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U.

Clin Cancer Res. 2011 Jan 1;17(1):111-21. doi: 10.1158/1078-0432.CCR-10-2075.

9.

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths.

Kimura M, Stone RC, Hunt SC, Skurnick J, Lu X, Cao X, Harley CB, Aviv A.

Nat Protoc. 2010 Sep;5(9):1596-607. doi: 10.1038/nprot.2010.124. Epub 2010 Sep 2.

PMID:
21085125
10.

In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator.

Zhu J, Lee S, Ho MK, Hu Y, Pang H, Ip FC, Chin AC, Harley CB, Ip NY, Wong YH.

Drug Metab Pharmacokinet. 2010;25(5):477-86. Epub 2010 Sep 22.

11.

A natural product telomerase activator as part of a health maintenance program.

Harley CB, Liu W, Blasco M, Vera E, Andrews WH, Briggs LA, Raffaele JM.

Rejuvenation Res. 2011 Feb;14(1):45-56. doi: 10.1089/rej.2010.1085. Epub 2010 Sep 7.

12.

Imetelstat (GRN163L)--telomerase-based cancer therapy.

Röth A, Harley CB, Baerlocher GM.

Recent Results Cancer Res. 2010;184:221-34. doi: 10.1007/978-3-642-01222-8_16. Review.

PMID:
20072842
13.

Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

Fauce SR, Jamieson BD, Chin AC, Mitsuyasu RT, Parish ST, Ng HL, Kitchen CM, Yang OO, Harley CB, Effros RB.

J Immunol. 2008 Nov 15;181(10):7400-6.

14.

Telomerase and cancer therapeutics.

Harley CB.

Nat Rev Cancer. 2008 Mar;8(3):167-79. doi: 10.1038/nrc2275. Review.

PMID:
18256617
15.

Adenoviral human telomerase reverse transcriptase dramatically improves ischemic wound healing without detrimental immune response in an aged rabbit model.

Mogford JE, Liu WR, Reid R, Chiu CP, Said H, Chen SJ, Harley CB, Mustoe TA.

Hum Gene Ther. 2006 Jun;17(6):651-60.

PMID:
16776573
16.

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma.

Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S, Harley CB, Rudolph KL.

Hepatology. 2005 Nov;42(5):1127-36.

PMID:
16114043
17.

Telomerase therapeutics for degenerative diseases.

Harley CB.

Curr Mol Med. 2005 Mar;5(2):205-11. Review.

PMID:
15974874
18.

Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.

Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM.

Oncogene. 2005 Aug 4;24(33):5262-8.

PMID:
15940257
19.

The aging factor in health and disease: the promise of basic research on aging.

Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE.

Aging Clin Exp Res. 2004 Apr;16(2):104-11; discussion 111-2. Review. No abstract available.

PMID:
15195984
20.

Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms.

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Moskovitz AH, Gryaznov S, Harley CB, Rabinovitch PS.

Cytometry A. 2004 Apr;58(2):120-31.

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