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Items: 1 to 20 of 36


Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.

Mohammed S, Harikumar KB.

Front Immunol. 2017 Mar 14;8:296. doi: 10.3389/fimmu.2017.00296. eCollection 2017. Review.


The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.


K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T.

Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26.


Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S.

Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27.


A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30.


Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics.

Van DN, Roberts CF, Marion JD, L├ępine S, Harikumar KB, Schreiter J, Dumur CI, Fang X, Spiegel S, Bell JK.

FASEB J. 2012 Aug;26(8):3188-98. doi: 10.1096/fj.11-202333. Epub 2012 Apr 24.


Extracellular and intracellular sphingosine-1-phosphate in cancer.

Yester JW, Tizazu E, Harikumar KB, Kordula T.

Cancer Metastasis Rev. 2011 Dec;30(3-4):577-97. doi: 10.1007/s10555-011-9305-0. Review.


Sphingosine-1-phosphate signaling and its role in disease.

Maceyka M, Harikumar KB, Milstien S, Spiegel S.

Trends Cell Biol. 2012 Jan;22(1):50-60. doi: 10.1016/j.tcb.2011.09.003. Epub 2011 Oct 14. Review.


Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.


Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products.

Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB.

Mol Cancer Res. 2010 May;8(5):751-61. doi: 10.1158/1541-7786.MCR-09-0565. Epub 2010 May 11.


A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.

Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh].


Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Takabe K, Kim RH, Allegood JC, Mitra P, Ramachandran S, Nagahashi M, Harikumar KB, Hait NC, Milstien S, Spiegel S.

J Biol Chem. 2010 Apr 2;285(14):10477-86. doi: 10.1074/jbc.M109.064162. Epub 2010 Jan 28.


Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB.

Mol Pharmacol. 2010 May;77(5):818-27. doi: 10.1124/mol.109.062760. Epub 2010 Jan 26.


Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009.

Anchoori RK, Harikumar KB, Batchu VR, Aggarwal BB, Khan SR.

Bioorg Med Chem. 2010 Jan 1;18(1):229-35. doi: 10.1016/j.bmc.2009.10.065. Epub 2009 Nov 4.


Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer.

Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB.

Int J Cancer. 2010 Jul 15;127(2):257-68. doi: 10.1002/ijc.25041. Erratum in: Int J Cancer. 2015 Dec 15;137(12):E21.


Inhibition of viral carcinogenesis by Phyllanthus amarus.

Harikumar KB, Kuttan G, Kuttan R.

Integr Cancer Ther. 2009 Sep;8(3):254-60. doi: 10.1177/1534735409340162. Erratum in: Integr Cancer Ther. 2010 Mar;9(1):122.


Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.

Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Erratum in: Science. 2009 Oct 16;326(5951):366.


Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B.

Ann N Y Acad Sci. 2009 Aug;1171:59-76. doi: 10.1111/j.1749-6632.2009.04911.x. Review.


Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.

Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB.

Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Erratum in: Int J Cancer. 2010 Feb 1;126(3):799. Kuzhuvelil, Harikumar B [corrected to Harikumar, Kuzhuvelil B].


Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis.

Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B.

Exp Biol Med (Maywood). 2009 Aug;234(8):825-49. doi: 10.3181/0902-MR-78. Epub 2009 Jun 2. Review.

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