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Items: 1 to 20 of 313

1.

Epigenetics of T cell aging.

Goronzy JJ, Hu B, Kim C, Jadhav RR, Weyand CM.

J Leukoc Biol. 2018 Jun 27. doi: 10.1002/JLB.1RI0418-160R. [Epub ahead of print] Review.

PMID:
29947427
2.

Vaccination programs for older adults in an era of demographic change.

Doherty TM, Connolly MP, Del Giudice G, Flamaing J, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Maggi S, McElhaney JE, Nagai H, Schaffner W, Schmidt-Ott R, Walsh E, Di Pasquale A.

Eur Geriatr Med. 2018;9(3):289-300. doi: 10.1007/s41999-018-0040-8. Epub 2018 Mar 19. Review.

3.

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease.

Weyand CM, Shen Y, Goronzy JJ.

Free Radic Biol Med. 2018 Mar 7. pii: S0891-5849(18)30107-2. doi: 10.1016/j.freeradbiomed.2018.03.004. [Epub ahead of print] Review.

PMID:
29524605
4.

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.

Zeisbrich M, Yanes RE, Zhang H, Watanabe R, Li Y, Brosig L, Hong J, Wallis BB, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM.

Ann Rheum Dis. 2018 Jul;77(7):1053-1062. doi: 10.1136/annrheumdis-2017-212647. Epub 2018 Feb 3.

PMID:
29431119
5.

Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging.

Del Giudice G, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Mrkvan T, Stoddard JJ, Doherty TM.

NPJ Aging Mech Dis. 2017 Dec 21;4:1. doi: 10.1038/s41514-017-0020-0. eCollection 2018.

6.

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis.

Zhang H, Watanabe R, Berry GJ, Tian L, Goronzy JJ, Weyand CM.

Circulation. 2018 May 1;137(18):1934-1948. doi: 10.1161/CIRCULATIONAHA.117.030423. Epub 2017 Dec 18.

PMID:
29254929
7.

Origin and differentiation of human memory CD8 T cells after vaccination.

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R.

Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13.

8.

DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.

Li Y, Goronzy JJ, Weyand CM.

Exp Gerontol. 2018 May;105:118-127. doi: 10.1016/j.exger.2017.10.027. Epub 2017 Nov 8. Review.

PMID:
29101015
9.

The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.

Weyand CM, Berry GJ, Goronzy JJ.

J Leukoc Biol. 2018 Mar;103(3):565-575. doi: 10.1189/jlb.3MA0717-283. Epub 2017 Dec 29.

PMID:
28848042
10.

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells.

Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM.

Nat Immunol. 2017 Sep;18(9):1025-1034. doi: 10.1038/ni.3808. Epub 2017 Jul 24.

11.

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.

Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaal3322. doi: 10.1126/scitranslmed.aal3322.

PMID:
28724574
12.

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.

Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.

13.

Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.

Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM.

J Clin Invest. 2017 Jun 30;127(7):2725-2738. doi: 10.1172/JCI92167. Epub 2017 Jun 12.

14.

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis.

Weyand CM, Zeisbrich M, Goronzy JJ.

Curr Opin Immunol. 2017 Jun;46:112-120. doi: 10.1016/j.coi.2017.04.010. Epub 2017 May 21. Review.

15.

Epigenomics of human CD8 T cell differentiation and aging.

Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ.

Sci Immunol. 2017 Feb;2(8). pii: eaag0192. doi: 10.1126/sciimmunol.aag0192. Epub 2017 Feb 17.

16.

Immunometabolism in early and late stages of rheumatoid arthritis.

Weyand CM, Goronzy JJ.

Nat Rev Rheumatol. 2017 May;13(5):291-301. doi: 10.1038/nrrheum.2017.49. Epub 2017 Mar 31. Review.

PMID:
28360422
17.

Successful and Maladaptive T Cell Aging.

Goronzy JJ, Weyand CM.

Immunity. 2017 Mar 21;46(3):364-378. doi: 10.1016/j.immuni.2017.03.010. Review.

18.

Immune checkpoint dysfunction in large and medium vessel vasculitis.

Watanabe R, Zhang H, Berry G, Goronzy JJ, Weyand CM.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1052-H1059. doi: 10.1152/ajpheart.00024.2017. Epub 2017 Mar 17. Review.

19.

Clinical and pathological evolution of giant cell arteritis: a prospective study of follow-up temporal artery biopsies in 40 treated patients.

Maleszewski JJ, Younge BR, Fritzlen JT, Hunder GG, Goronzy JJ, Warrington KJ, Weyand CM.

Mod Pathol. 2017 Jun;30(6):788-796. doi: 10.1038/modpathol.2017.10. Epub 2017 Mar 3.

20.

Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.

Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E970-E979. doi: 10.1073/pnas.1616848114. Epub 2017 Jan 23.

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