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Items: 1 to 20 of 103


PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.

Henkels KM, Muppani NR, Gomez-Cambronero J.

PLoS One. 2016 Nov 16;11(11):e0166553. doi: 10.1371/journal.pone.0166553.


A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis.

Henkels KM, Miller TE, Ganesan R, Wilkins BA, Fite K, Gomez-Cambronero J.

Oncotarget. 2016 Jul 26;7(30):47002-47017. doi: 10.18632/oncotarget.9685.


A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells.

Fite K, Elkhadragy L, Gomez-Cambronero J.

Mol Cell Biol. 2016 Jan 19;36(7):1078-89. doi: 10.1128/MCB.00711-15.


The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.

Ganesan R, Mallets E, Gomez-Cambronero J.

Mol Oncol. 2016 May;10(5):663-76. doi: 10.1016/j.molonc.2015.12.006.


Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.

Fite K, Gomez-Cambronero J.

J Biol Chem. 2016 Jan 8;291(2):719-30. doi: 10.1074/jbc.M115.686006.


Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells.

Mahankali M, Farkaly T, Bedi S, Hostetler HA, Gomez-Cambronero J.

Sci Rep. 2015 Oct 23;5:15379. doi: 10.1038/srep15379.


Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor.

Hatton N, Lintz E, Mahankali M, Henkels KM, Gomez-Cambronero J.

Mol Cell Biol. 2015 Sep;35(18):3131-44. doi: 10.1128/MCB.00286-15.


Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response.

Kotha PL, Sharma P, Kolawole AO, Yan R, Alghamri MS, Brockman TL, Gomez-Cambronero J, Excoffon KJ.

PLoS Pathog. 2015 Mar 13;11(3):e1004696. doi: 10.1371/journal.ppat.1004696.


FASEB Science Research Conference on phospholipid cell signaling and metabolism in inflammation and cancer.

Gomez-Cambronero J.

FASEB J. 2015 Jan;29(1):5-10. doi: 10.1096/fj.15-0102ufm. No abstract available.


Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.

Ganesan R, Mahankali M, Alter G, Gomez-Cambronero J.

Biochim Biophys Acta. 2015 Mar;1851(3):261-72. doi: 10.1016/j.bbalip.2014.12.007.


S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding.

Henkels KM, Mallets ER, Dennis PB, Gomez-Cambronero J.

FASEB J. 2015 Apr;29(4):1299-313. doi: 10.1096/fj.14-260992.


A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src.

Mahankali M, Henkels KM, Speranza F, Gomez-Cambronero J.

J Cell Sci. 2015 Feb 1;128(3):516-26.


Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.

Mahankali M, Alter G, Gomez-Cambronero J.

Cell Signal. 2015 Jan;27(1):69-81. doi: 10.1016/j.cellsig.2014.09.008.


The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.

Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J.

J Biol Chem. 2014 Oct 17;289(42):28885-97. doi: 10.1074/jbc.M114.597146.


A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling.

Gomez-Cambronero J, Kantonen S.

J Leukoc Biol. 2014 Nov;96(5):779-84. doi: 10.1189/jlb.2VMR0214-120RR. Review.


Thematic minireview series on phospholipase D and cancer.

Gomez-Cambronero J, Carman GM.

J Biol Chem. 2014 Aug 15;289(33):22554-6. doi: 10.1074/jbc.R114.593137.


Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

Gomez-Cambronero J.

J Biol Chem. 2014 Aug 15;289(33):22557-66. doi: 10.1074/jbc.R114.574152. Review.


Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.

Usatyuk PV, Fu P, Mohan V, Epshtein Y, Jacobson JR, Gomez-Cambronero J, Wary KK, Bindokas V, Dudek SM, Salgia R, Garcia JG, Natarajan V.

J Biol Chem. 2014 May 9;289(19):13476-91. doi: 10.1074/jbc.M113.527556.


Phosphatidic acid, phospholipase D and tumorigenesis.

Gomez-Cambronero J.

Adv Biol Regul. 2014 Jan;54:197-206. doi: 10.1016/j.jbior.2013.08.006.


Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression.

Speranza FJ, Mahankali M, Gomez-Cambronero J.

J Leukoc Biol. 2013 Nov;94(5):953-62. doi: 10.1189/jlb.0313174.

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