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Items: 1 to 20 of 191


Mechanism of antineoplastic activity of lonidamine.

Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD.

Biochim Biophys Acta. 2016 Dec;1866(2):151-162. doi: 10.1016/j.bbcan.2016.08.001. Epub 2016 Aug 4. Review.


(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.

Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD.

Front Oncol. 2016 Jun 15;6:135. doi: 10.3389/fonc.2016.00135. eCollection 2016.


Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.

Nath K, Nelson DS, Putt ME, Leeper DB, Garman B, Nathanson KL, Glickson JD.

PLoS One. 2016 Jun 10;11(6):e0157125. doi: 10.1371/journal.pone.0157125. eCollection 2016.


The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP.

Biochem J. 2016 Apr 1;473(7):929-36. doi: 10.1042/BJ20151120. Epub 2016 Feb 1.


Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells.

Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD.

J Biol Chem. 2016 Mar 4;291(10):5157-71. doi: 10.1074/jbc.M115.701862. Epub 2015 Dec 24.


Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine.

Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA.

J Biol Chem. 2016 Jan 1;291(1):42-57. doi: 10.1074/jbc.M115.697516. Epub 2015 Oct 31.


Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan.

Nath K, Nelson DS, Heitjan DF, Zhou R, Leeper DB, Glickson JD.

NMR Biomed. 2015 Mar;28(3):395-403. doi: 10.1002/nbm.3260.


Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin.

Nath K, Nelson DS, Heitjan DF, Leeper DB, Zhou R, Glickson JD.

NMR Biomed. 2015 Mar;28(3):281-90. doi: 10.1002/nbm.3240. Epub 2014 Dec 12.


The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and (13) C-isotope based metabolomics.

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA.

NMR Biomed. 2014 Apr;27(4):381-9. doi: 10.1002/nbm.3072. Epub 2014 Feb 4.


Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate.

Xu HN, Kadlececk S, Profka H, Glickson JD, Rizi R, Li LZ.

Acad Radiol. 2014 Feb;21(2):223-31. doi: 10.1016/j.acra.2013.11.014.


Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

Arias-Mendoza F, Payne GS, Zakian K, Stubbs M, O'Connor OA, Mojahed H, Smith MR, Schwarz AJ, Shukla-Dave A, Howe F, Poptani H, Lee SC, Pettengel R, Schuster SJ, Cunningham D, Heerschap A, Glickson JD, Griffiths JR, Koutcher JA, Leach MO, Brown TR.

Acad Radiol. 2013 Sep;20(9):1122-9. doi: 10.1016/j.acra.2013.04.013.


Mapping the redox state of CHOP-treated non-Hodgkin's lymphoma xenografts in mice.

Xu HN, Mir TA, Lee SC, Feng M, Farhad N, Choe R, Glickson JD, Li LZ.

Adv Exp Med Biol. 2013;789:243-9. doi: 10.1007/978-1-4614-7411-1_33.



Xu HN, Zhao H, Mir TA, Lee SC, Feng M, Choe R, Glickson JD, Li LZ.

J Innov Opt Health Sci. 2013 Apr;6(2):1350011.


Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume.

Paudyal R, Poptani H, Cai K, Zhou R, Glickson JD.

J Magn Reson Imaging. 2013 Feb;37(2):435-44. doi: 10.1002/jmri.23837. Epub 2012 Nov 29.


Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy.

Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD.

J Liver Disease Transplant. 2012 Sep 1;1(1). doi: 10.4172/2325-9612.1000101.


Metabolic network analysis of DB1 melanoma cells: how much energy is derived from aerobic glycolysis?

Shestov AA, Mancuso A, Leeper DB, Glickson JD.

Adv Exp Med Biol. 2013;765:265-71. doi: 10.1007/978-1-4614-4989-8_37.


Lactate detection in inducible and orthotopic Her2/neu mammary gland tumours in mouse models.

Magnitsky S, Belka GK, Sterner C, Pickup S, Chodosh LA, Glickson JD.

NMR Biomed. 2013 Jan;26(1):35-42. doi: 10.1002/nbm.2816. Epub 2012 Jul 5.


(31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan.

Nath K, Nelson DS, Ho AM, Lee SC, Darpolor MM, Pickup S, Zhou R, Heitjan DF, Leeper DB, Glickson JD.

NMR Biomed. 2013 Jan;26(1):98-105. doi: 10.1002/nbm.2824. Epub 2012 Jun 29.


Prediction and Early Detection of Response by NMR Spectroscopy and Imaging.

Lee SC, Arias-Mendoza F, Poptani H, Delikatny EJ, Wasik M, Marzec M, Schuster SJ, Nasta SD, Svoboda J, O'Connor OA, Smith MR, Glickson JD.

PET Clin. 2012 Jan;7(1):119-26. doi: 10.1016/j.cpet.2011.12.007. No abstract available.

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