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Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors.

Herrera-Martínez AD, Gahete MD, Sánchez-Sánchez R, Alors-Perez E, Pedraza-Arevalo S, Serrano-Blanch R, Martínez-Fuentes AJ, Gálvez-Moreno MA, Castaño JP, Luque RM.

Clin Transl Gastroenterol. 2018 Oct 8;9(10):196. doi: 10.1038/s41424-018-0058-8.


Multilayered heterogeneity as an intrinsic hallmark of neuroendocrine tumors.

Pedraza-Arévalo S, Gahete MD, Alors-Pérez E, Luque RM, Castaño JP.

Rev Endocr Metab Disord. 2018 Oct 6. doi: 10.1007/s11154-018-9465-0. [Epub ahead of print] Review.


Type 2 diabetes in neuroendocrine tumors: are biguanides and statins part of the solution?

Herrera-Martínez AD, Pedraza-Arevalo S, L-López F, Gahete MD, Gálvez-Moreno MA, Castaño JP, Luque RM.

J Clin Endocrinol Metab. 2018 Sep 27. doi: 10.1210/jc.2018-01455. [Epub ahead of print]


Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer.

Gómez-Gómez E, Jiménez-Vacas JM, Carrasco-Valiente J, Herrero-Aguayo V, Blanca-Pedregosa AM, León-González AJ, Valero-Rosa J, Fernández-Rueda JL, González-Serrano T, López-Miranda J, Gahete MD, Castaño JP, Requena-Tapia MJ, Luque RM.

J Cell Mol Med. 2018 Sep 6. doi: 10.1111/jcmm.13845. [Epub ahead of print]


The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions.

Vázquez-Borrego MC, Fuentes-Fayos AC, Gahete MD, Castaño JP, Kineman RD, Luque RM.

Cell Physiol Biochem. 2018;49(4):1444-1459. doi: 10.1159/000493448. Epub 2018 Sep 11.


Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas.

Alhambra-Expósito MR, Ibáñez-Costa A, Moreno-Moreno P, Rivero-Cortés E, Vázquez-Borrego MC, Blanco-Acevedo C, Toledano-Delgado Á, Lombardo-Galera MS, Vallejo-Casas JA, Gahete MD, Castaño JP, Gálvez MA, Luque RM.

Sci Rep. 2018 Apr 18;8(1):6173. doi: 10.1038/s41598-018-24260-y.


In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines.

Rincón-Fernández D, Culler MD, Tsomaia N, Moreno-Bueno G, Luque RM, Gahete MD, Castaño JP.

Carcinogenesis. 2018 Mar 8;39(3):447-457. doi: 10.1093/carcin/bgx146.


Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

Vázquez-Borrego MC, Gahete MD, Martínez-Fuentes AJ, Fuentes-Fayos AC, Castaño JP, Kineman RD, Luque RM.

Mol Cell Endocrinol. 2018 Mar 5;463:4-22. doi: 10.1016/j.mce.2017.12.007. Epub 2017 Dec 16. Review.


Clinical and functional implication of the components of somatostatin system in gastroenteropancreatic neuroendocrine tumors.

Herrera-Martínez AD, Gahete MD, Pedraza-Arevalo S, Sánchez-Sánchez R, Ortega-Salas R, Serrano-Blanch R, Luque RM, Gálvez-Moreno MA, Castaño JP.

Endocrine. 2018 Feb;59(2):426-437. doi: 10.1007/s12020-017-1482-3. Epub 2017 Dec 1.


Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients.

Luque RM, López-Sánchez LM, Villa-Osaba A, Luque IM, Santos-Romero AL, Yubero-Serrano EM, Cara-García M, Álvarez-Benito M, López-Mirand A J, Gahete MD, Castaño JP.

Oncotarget. 2017 Aug 23;8(46):81462-81474. doi: 10.18632/oncotarget.20399. eCollection 2017 Oct 6.


Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer.

Pedraza-Arévalo S, Hormaechea-Agulla D, Gómez-Gómez E, Requena MJ, Selth LA, Gahete MD, Castaño JP, Luque RM.

Prostate. 2017 Nov;77(15):1499-1511. doi: 10.1002/pros.23426. Epub 2017 Sep 14.


The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness.

Hormaechea-Agulla D, Gahete MD, Jiménez-Vacas JM, Gómez-Gómez E, Ibáñez-Costa A, L-López F, Rivero-Cortés E, Sarmento-Cabral A, Valero-Rosa J, Carrasco-Valiente J, Sánchez-Sánchez R, Ortega-Salas R, Moreno MM, Tsomaia N, Swanson SM, Culler MD, Requena MJ, Castaño JP, Luque RM.

Mol Cancer. 2017 Aug 29;16(1):146. doi: 10.1186/s12943-017-0713-9.


The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer.

Hormaechea-Agulla D, Jiménez-Vacas JM, Gómez-Gómez E, L-López F, Carrasco-Valiente J, Valero-Rosa J, Moreno MM, Sánchez-Sánchez R, Ortega-Salas R, Gracia-Navarro F, Culler MD, Ibáñez-Costa A, Gahete MD, Requena MJ, Castaño JP, Luque RM.

FASEB J. 2017 Nov;31(11):4682-4696. doi: 10.1096/fj.201601264RRR. Epub 2017 Jul 13.


The components of somatostatin and ghrelin systems are altered in neuroendocrine lung carcinoids and associated to clinical-histological features.

Herrera-Martínez AD, Gahete MD, Sánchez-Sánchez R, Salas RO, Serrano-Blanch R, Salvatierra Á, Hofland LJ, Luque RM, Gálvez-Moreno MA, Castaño JP.

Lung Cancer. 2017 Jul;109:128-136. doi: 10.1016/j.lungcan.2017.05.006. Epub 2017 May 13.


Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways.

Sarmento-Cabral A, L-López F, Gahete MD, Castaño JP, Luque RM.

Mol Cancer Res. 2017 Jul;15(7):862-874. doi: 10.1158/1541-7786.MCR-16-0493. Epub 2017 Apr 6.


Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.

L-López F, Sarmento-Cabral A, Herrero-Aguayo V, Gahete MD, Castaño JP, Luque RM.

J Cell Mol Med. 2017 Sep;21(9):1893-1904. doi: 10.1111/jcmm.13109. Epub 2017 Feb 28.


BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.

Ibáñez-Costa A, López-Sánchez LM, Gahete MD, Rivero-Cortés E, Vázquez-Borrego MC, Gálvez MA, de la Riva A, Venegas-Moreno E, Jiménez-Reina L, Moreno-Carazo A, Tinahones FJ, Maraver-Selfa S, Japón MA, García-Arnés JA, Soto-Moreno A, Webb SM, Kineman RD, Culler MD, Castaño JP, Luque RM.

Sci Rep. 2017 Feb 9;7:42002. doi: 10.1038/srep42002.


Models of GH deficiency in animal studies.

Gahete MD, Luque RM, Castaño JP.

Best Pract Res Clin Endocrinol Metab. 2016 Dec;30(6):693-704. doi: 10.1016/j.beem.2016.11.001. Epub 2016 Nov 4. Review.


Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP.

Sci Rep. 2016 Nov 30;6:37992. doi: 10.1038/srep37992.


Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker.

Hormaechea-Agulla D, Gómez-Gómez E, Ibáñez-Costa A, Carrasco-Valiente J, Rivero-Cortés E, L-López F, Pedraza-Arevalo S, Valero-Rosa J, Sánchez-Sánchez R, Ortega-Salas R, Moreno MM, Gahete MD, López-Miranda J, Requena MJ, Castaño JP, Luque RM.

Cancer Lett. 2016 Dec 1;383(1):125-134. doi: 10.1016/j.canlet.2016.09.022. Epub 2016 Sep 28.


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