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Items: 1 to 20 of 204


Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation, and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E Oligomers.

Wang H, Eschweiler J, Cui W, Zhang H, Frieden C, Ruotolo BT, Gross ML.

J Am Soc Mass Spectrom. 2019 May;30(5):876-885. doi: 10.1007/s13361-019-02148-z. Epub 2019 Mar 18.


Protein oligomerization as a metabolic control mechanism: Application to apoE.

Frieden C.

Protein Sci. 2019 Apr;28(4):837-842. doi: 10.1002/pro.3583. Epub 2019 Feb 18.


Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.

Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR.

mBio. 2018 Jul 17;9(4). pii: e01349-18. doi: 10.1128/mBio.01349-18.


Understanding Curli Amyloid-Protein Aggregation by Hydrogen-Deuterium Exchange and Mass Spectrometry.

Wang H, Shu Q, Rempel DL, Frieden C, Gross ML.

Int J Mass Spectrom. 2017 Sep;420:16-23. doi: 10.1016/j.ijms.2016.10.006. Epub 2016 Oct 11.


Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen-Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3.

Wang H, Rempel DL, Giblin D, Frieden C, Gross ML.

Anal Chem. 2017 Oct 17;89(20):10687-10695. doi: 10.1021/acs.analchem.7b01121. Epub 2017 Sep 25.


A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions.

Frieden C, Wang H, Ho CMW.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6292-6297. doi: 10.1073/pnas.1705080114. Epub 2017 May 30.


Deamidation Slows Curli Amyloid-Protein Aggregation.

Wang H, Shu Q, Frieden C, Gross ML.

Biochemistry. 2017 Jun 13;56(23):2865-2872. doi: 10.1021/acs.biochem.7b00241. Epub 2017 May 26.


Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.

Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7130-5. doi: 10.1073/pnas.1607222113. Epub 2016 Jun 13.


ApoE: In Vitro Studies of a Small Molecule Effector.

Mondal T, Wang H, DeKoster GT, Baban B, Gross ML, Frieden C.

Biochemistry. 2016 May 10;55(18):2613-21. doi: 10.1021/acs.biochem.6b00324. Epub 2016 Apr 27.


Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization.

Wang H, Shu Q, Rempel DL, Frieden C, Gross ML.

Biochemistry. 2015 Oct 27;54(42):6475-81. doi: 10.1021/acs.biochem.5b00871. Epub 2015 Oct 14.


ApoE: the role of conserved residues in defining function.

Frieden C.

Protein Sci. 2015 Jan;24(1):138-44. doi: 10.1002/pro.2597. Epub 2014 Dec 9.


The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.

Garai K, Verghese PB, Baban B, Holtzman DM, Frieden C.

Biochemistry. 2014 Oct 14;53(40):6323-31. doi: 10.1021/bi5008172. Epub 2014 Sep 25.


Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.

Crick SL, Ruff KM, Garai K, Frieden C, Pappu RV.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20075-80. doi: 10.1073/pnas.1320626110. Epub 2013 Nov 26.


Concerning the structure of apoE.

Frieden C, Garai K.

Protein Sci. 2013 Dec;22(12):1820-5. doi: 10.1002/pro.2379. Epub 2013 Oct 19.


ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.

Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1807-16. doi: 10.1073/pnas.1220484110. Epub 2013 Apr 25.


Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ.

Garai K, Frieden C.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3321-6. doi: 10.1073/pnas.1222478110. Epub 2013 Feb 11.


Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.

Frieden C, Garai K.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8913-8. doi: 10.1073/pnas.1207022109. Epub 2012 May 21. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13130.


The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.

Shu Q, Crick SL, Pinkner JS, Ford B, Hultgren SJ, Frieden C.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6502-7. doi: 10.1073/pnas.1204161109. Epub 2012 Apr 9.


Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization.

Huang RY, Garai K, Frieden C, Gross ML.

Biochemistry. 2011 Nov 1;50(43):9273-82. doi: 10.1021/bi2010027. Epub 2011 Oct 5.


Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3, and E4.

Gau B, Garai K, Frieden C, Gross ML.

Biochemistry. 2011 Sep 27;50(38):8117-26. doi: 10.1021/bi200911c. Epub 2011 Sep 2.

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