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β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2019 Jan;11(1). pii: e9466. doi: 10.15252/emmm.201809466.


Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC.

Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038/s41598-018-32190-y.


Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans.

Rusanova I, Diaz-Casado ME, Fernández-Ortiz M, Aranda-Martínez P, Guerra-Librero A, García-García FJ, Escames G, Mañas L, Acuña-Castroviejo D.

Oxid Med Cell Longev. 2018 Jul 18;2018:7671850. doi: 10.1155/2018/7671850. eCollection 2018.


The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Rusanova I, Rahim I, Escames G, López LC, Mokhtar DM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093/gerona/gly059.


Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.

Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12461. Epub 2018 Jan 9.


In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Díaz-Casado ME, Rusanova I, Aranda P, Fernández-Ortiz M, Sayed RKA, Fernández-Gil BI, Hidalgo-Gutiérrez A, Escames G, López LC, Acuña-Castroviejo D.

Zebrafish. 2018 Feb;15(1):15-26. doi: 10.1089/zeb.2017.1479. Epub 2017 Nov 29.


Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.

Ortiz-Franco M, Planells E, Quintero B, Acuña-Castroviejo D, Rusanova I, Escames G, Molina-López J.

Int J Sports Med. 2017 Dec;38(14):1117-1125. doi: 10.1055/s-0043-119881. Epub 2017 Nov 17.


Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López LC, Acuña-Castroviejo D.

PLoS One. 2017 Aug 11;12(8):e0183090. doi: 10.1371/journal.pone.0183090. eCollection 2017.


Melatonin, clock genes and mitochondria in sepsis.

Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G.

Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Review.


Oral Mucositis: Melatonin Gel an Effective New Treatment.

Abdel Moneim AE, Guerra-Librero A, Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D, Escames G.

Int J Mol Sci. 2017 May 7;18(5). pii: E1003. doi: 10.3390/ijms18051003. Review.


Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acuña-Castroviejo D, López LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G.

J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12415. Epub 2017 May 18.


Melatonin protects rats from radiotherapy-induced small intestine toxicity.

Fernández-Gil B, Moneim AE, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M, Guerra-Librero A, Acuña-Castroviejo D, Molina-Navarro MM, García-Verdugo JM, Sayed RK, Florido J, Luna JD, López LC, Escames G.

PLoS One. 2017 Apr 12;12(4):e0174474. doi: 10.1371/journal.pone.0174474. eCollection 2017.


Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Rahim I, Djerdjouri B, Sayed RK, Fernández-Ortiz M, Fernández-Gil B, Hidalgo-Gutiérrez A, López LC, Escames G, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2017 Aug;63(1). doi: 10.1111/jpi.12410. Epub 2017 Apr 29.


The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.

Leonardo-Mendonça RC, Ocaña-Wilhelmi J, de Haro T, de Teresa-Galván C, Guerra-Hernández E, Rusanova I, Fernández-Ortiz M, Sayed RKA, Escames G, Acuña-Castroviejo D.

Appl Physiol Nutr Metab. 2017 Jul;42(7):700-707. doi: 10.1139/apnm-2016-0677. Epub 2017 Feb 13.


Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.

García JA, Ortiz F, Miana J, Doerrier C, Fernández-Ortiz M, Rusanova I, Escames G, García JJ, Acuña-Castroviejo D.

J Physiol Biochem. 2017 May;73(2):235-244. doi: 10.1007/s13105-017-0548-2. Epub 2017 Jan 21.


CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2017 Jan;9(1):78-95. doi: 10.15252/emmm.201606345.


Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

Sayed RK, de Leonardis EC, Guerrero-Martínez JA, Rahim I, Mokhtar DM, Saleh AM, Abdalla KE, Pozo MJ, Escames G, López LC, Acuña-Castroviejo D.

Exp Gerontol. 2016 Oct;83:22-30. doi: 10.1016/j.exger.2016.07.007. Epub 2016 Jul 18.


Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network.

Díaz-Casado ME, Lima E, García JA, Doerrier C, Aranda P, Sayed RK, Guerra-Librero A, Escames G, López LC, Acuña-Castroviejo D.

J Pineal Res. 2016 Aug;61(1):96-107. doi: 10.1111/jpi.12332. Epub 2016 Apr 30.


Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network.

Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D.

Mitochondrion. 2016 Mar;27:56-63. doi: 10.1016/j.mito.2015.12.010. Epub 2015 Dec 31.


Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D.

J Pineal Res. 2016 Mar;60(2):193-205. doi: 10.1111/jpi.12303. Epub 2016 Jan 13.


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