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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.

Papillon JPN, Nakajima K, Adair CD, Hempel J, Jouk AO, Karki RG, Mathieu S, Möbitz H, Ntaganda R, Smith T, Visser M, Hill SE, Hurtado FK, Chenail G, Bhang HC, Bric A, Xiang K, Bushold G, Gilbert T, Vattay A, Dooley J, Costa EA, Park I, Li A, Farley D, Lounkine E, Yue QK, Xie X, Zhu X, Kulathila R, King D, Hu T, Vulic K, Cantwell J, Luu C, Jagani Z.

J Med Chem. 2018 Oct 31. doi: 10.1021/acs.jmedchem.8b01318. [Epub ahead of print]


Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators.

Lagou V, Garcia-Perez JE, Smets I, Van Horebeek L, Vandebergh M, Chen L, Mallants K, Prezzemolo T, Hilven K, Humblet-Baron S, Moisse M, Van Damme P, Boeckxstaens G, Bowness P, Dubois B, Dooley J, Liston A, Goris A.

Cell Rep. 2018 Oct 16;25(3):798-810.e6. doi: 10.1016/j.celrep.2018.09.048.


Moral reasoning and decision-making in adolescents who sustain traumatic brain injury.

Beauchamp MH, Vera-Estay E, Morasse F, Anderson V, Dooley J.

Brain Inj. 2018 Oct 16:1-8. doi: 10.1080/02699052.2018.1531307. [Epub ahead of print]


The Long Non-coding RNA Flatr Anticipates Foxp3 Expression in Regulatory T Cells.

Brajic A, Franckaert D, Burton O, Bornschein S, Calvanese AL, Demeyer S, Cools J, Dooley J, Schlenner S, Liston A.

Front Immunol. 2018 Sep 25;9:1989. doi: 10.3389/fimmu.2018.01989. eCollection 2018.


Involving patients with dementia in decisions to initiate treatment: effect on patient acceptance, satisfaction and medication prescription.

Dooley J, Bass N, Livingston G, McCabe R.

Br J Psychiatry. 2018 Oct 1:1-5. doi: 10.1192/bjp.2018.201. [Epub ahead of print]


ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease.

Van Nieuwenhove E, Humblet-Baron S, Van Eyck L, De Somer L, Dooley J, Tousseyn T, Hershfield M, Liston A, Wouters C.

Pediatrics. 2018 Sep;142(3). pii: e20172266. doi: 10.1542/peds.2017-2266.


Impact of Moderate Exercise on Post-concussive Symptoms and Cognitive Function after Concussion in Children and Adolescents Compared to Healthy Controls.

Anderson V, Manikas V, Babl FE, Hearps S, Dooley J.

Int J Sports Med. 2018 Sep;39(9):696-703. doi: 10.1055/a-0592-7512. Epub 2018 Aug 1.


Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors.

Zhao Q, Manning JR, Sutton J, Costales A, Sendzik M, Shafer CM, Levell JR, Liu G, Caferro T, Cho YS, Palermo M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Dodd S, Gould T, Liang G, Slocum K, Pu M, Firestone B, Growney J, Heimbach T, Pagliarini R.

ACS Med Chem Lett. 2018 Jun 11;9(7):746-751. doi: 10.1021/acsmedchemlett.8b00182. eCollection 2018 Jul 12.


Meningococcal Disease in Northern Ireland - Past, Present & Future: MeningoNI Forum.

Millar BC, Banks L, Bourke TW, Cunningham M, Dooley J, Elshibly S, Goldsmith CE, Fairley D, Jackson K, Lamont S, Jessop L, McCrudden E, McConnell D, McAuley K, McKenna JP, Moore P, Smithson R, Stirling J, Shields M, Moore JE.

Ulster Med J. 2018 May;87(2):83. Epub 2018 May 30.


De novo belatacept in clinical vascularized composite allotransplantation.

Cendales LC, Ruch DS, Cardones AR, Potter G, Dooley J, Dore D, Orr J, Ruskin G, Song M, Chen DF, Selim MA, Kirk AD.

Am J Transplant. 2018 Jul;18(7):1804-1809. doi: 10.1111/ajt.14910. Epub 2018 Jun 9.


A kindred with mutant IKAROS and autoimmunity.

Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A.

J Allergy Clin Immunol. 2018 Aug;142(2):699-702.e12. doi: 10.1016/j.jaci.2018.04.008. Epub 2018 Apr 27. No abstract available.


'How do they want to know?' Doctors' perspectives on making and communicating a diagnosis of dementia.

Bailey C, Dooley J, McCabe R.

Dementia (London). 2018 Jan 1:1471301218763904. doi: 10.1177/1471301218763904. [Epub ahead of print]


Maternal opioid use disorder and neonatal abstinence syndrome in northwest Ontario: a 7-year retrospective analysis.

Dooley J, Ryan G, Gerber Finn L, Bollinger M, Matsumoto CL, Hopman WM, Kelly L.

Can J Rural Med. 2018 Spring;23(2):39-44.


How do doctors deliver a diagnosis of dementia in memory clinics?

Dooley J, Bass N, McCabe R.

Br J Psychiatry. 2018 Apr;212(4):239-245. doi: 10.1192/bjp.2017.64. Epub 2018 Mar 12.


Selenium, Deficiency.

Shreenath AP, Dooley J.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Feb 20.


Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy.

Mavroidis P, Pearlstein KA, Dooley J, Sun J, Saripalli S, Das SK, Wang AZ, Chen RC.

Radiat Oncol. 2018 Feb 2;13(1):17. doi: 10.1186/s13014-018-0961-x.


Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells.

Smets I, Fiddes B, Garcia-Perez JE, He D, Mallants K, Liao W, Dooley J, Wang G, Humblet-Baron S, Dubois B, Compston A, Jones J, Coles A, Liston A, Ban M, Goris A, Sawcer S.

Brain. 2018 Jan 18. doi: 10.1093/brain/awx372. [Epub ahead of print]


Nonpharmacological management of neonatal abstinence syndrome: a review of the literature.

Ryan G, Dooley J, Gerber Finn L, Kelly L.

J Matern Fetal Neonatal Med. 2018 Jan 8:1-6. doi: 10.1080/14767058.2017.1414180. [Epub ahead of print]


NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer.

Dooley J, Pasciuto E, Lagou V, Lampi Y, Dresselaers T, Himmelreich U, Liston A.

Oncotarget. 2017 Sep 24;8(46):80167-80174. doi: 10.18632/oncotarget.21261. eCollection 2017 Oct 6.


Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.

Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD.

ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12.

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