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Items: 1 to 20 of 88


Catalog of Differentially Expressed Long Non-Coding RNA following Activation of Human and Mouse Innate Immune Response.

Roux BT, Heward JA, Donnelly LE, Jones SW, Lindsay MA.

Front Immunol. 2017 Aug 29;8:1038. doi: 10.3389/fimmu.2017.01038. eCollection 2017.


Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients.

Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ.

Am J Respir Crit Care Med. 2017 Jul 28. doi: 10.1164/rccm.201706-1304LE. [Epub ahead of print] No abstract available.


Correcting the "Wandering" Neutrophil with Statins. A Novel Antiaging Strategy?

Belchamber KBR, Donnelly LE.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1243-1244. doi: 10.1164/rccm.201707-1410ED. No abstract available.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD.

Yanagisawa S, Baker JR, Vuppusetty C, Fenwick P, Donnelly LE, Ito K, Barnes PJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L230-L239. doi: 10.1152/ajplung.00382.2016. Epub 2017 May 18.


Macrophage Dysfunction in Respiratory Disease.

Belchamber KBR, Donnelly LE.

Results Probl Cell Differ. 2017;62:299-313. doi: 10.1007/978-3-319-54090-0_12. Review.


Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism.

Yeo SCM, Fenwick PS, Barnes PJ, Lin HS, Donnelly LE.

Br J Pharmacol. 2017 Jul;174(13):2043-2059. doi: 10.1111/bph.13803. Epub 2017 May 16.


Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Bewley MA, Belchamber KB, Chana KK, Budd RC, Donaldson G, Wedzicha JA, Brightling CE, Kilty I, Donnelly LE, Barnes PJ, Singh D, Whyte MK, Dockrell DH; COPDMAP.

PLoS One. 2016 Sep 28;11(9):e0163139. doi: 10.1371/journal.pone.0163139. eCollection 2016.


A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects.

Nicholson GC, Holloway RA, Leaker BR, Kilty I, Salganik M, Tan L, Barnes PJ, Donnelly LE.

BMJ Open Respir Res. 2016 Jun 22;3(1):e000140. doi: 10.1136/bmjresp-2016-000140. eCollection 2016.


Could Protecting the Immunoproteasome Reduce Exacerbations in Chronic Obstructive Pulmonary Disease?

Donnelly LE.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1188-90. doi: 10.1164/rccm.201601-0060ED. No abstract available.


Now We Know Who You Are: A Clear Description of Mononuclear Phagocyte Subsets in the Human Lung.

Singh D, Donnelly LE.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):594-6. doi: 10.1164/rccm.201511-2212ED. No abstract available.


Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD.

Costa C, Traves SL, Tudhope SJ, Fenwick PS, Belchamber KB, Russell RE, Barnes PJ, Donnelly LE.

Eur Respir J. 2016 Apr;47(4):1093-102.


Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells.

Fenwick PS, Macedo P, Kilty IC, Barnes PJ, Donnelly LE.

PLoS One. 2015 Jun 19;10(6):e0128757. doi: 10.1371/journal.pone.0128757. eCollection 2015.


Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

Ilott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, Donnelly LE, Sims D, Lindsay MA.

Nat Commun. 2015 Apr 9;6:6814. doi: 10.1038/ncomms7814. No abstract available.


Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease.

Singh R, Mackay AJ, Patel AR, Garcha DS, Kowlessar BS, Brill SE, Donnelly LE, Barnes PJ, Donaldson GC, Wedzicha JA.

Respir Res. 2014 Sep 14;15:114. doi: 10.1186/s12931-014-0114-1.


The lipidome: a new player in chronic obstructive pulmonary disease pathophysiology?

Donnelly LE.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):124-5. doi: 10.1164/rccm.201406-1061ED. No abstract available.


Impaired macrophage phagocytosis of bacteria in severe asthma.

Liang Z, Zhang Q, Thomas CM, Chana KK, Gibeon D, Barnes PJ, Chung KF, Bhavsar PK, Donnelly LE.

Respir Res. 2014 Jun 27;15:72. doi: 10.1186/1465-9921-15-72.


Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes.

IIott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, Donnelly LE, Sims D, Lindsay MA.

Nat Commun. 2014 Jun 9;5:3979. doi: 10.1038/ncomms4979. Erratum in: Nat Commun. 2015;6:6814.


Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses.

Forbes B, O'Lone R, Allen PP, Cahn A, Clarke C, Collinge M, Dailey LA, Donnelly LE, Dybowski J, Hassall D, Hildebrand D, Jones R, Kilgour J, Klapwijk J, Maier CC, McGovern T, Nikula K, Parry JD, Reed MD, Robinson I, Tomlinson L, Wolfreys A.

Adv Drug Deliv Rev. 2014 May;71:15-33. doi: 10.1016/j.addr.2014.02.001. Epub 2014 Feb 13.


Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease.

Chana KK, Fenwick PS, Nicholson AG, Barnes PJ, Donnelly LE.

J Allergy Clin Immunol. 2014 Jan;133(1):207-16.e1-11. doi: 10.1016/j.jaci.2013.08.044. Epub 2013 Oct 28.


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