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Cytokine Growth Factor Rev. 2015 Apr;26(2):179-82. doi: 10.1016/j.cytogfr.2014.10.006. Epub 2014 Oct 31.

High efficiency targeting of IFN-α activity: possible applications in fighting tumours and infections.

Author information

1
CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France. Electronic address: uze@univ-montp2.fr.
2
Department of Medical Protein Research, Flanders Institute for Biotechnology, Ghent University, Faculty of Medicine and Health Sciences, Ghent, BE 9000, Belgium. Electronic address: jan.tavernier@vib-ugent.be.

Abstract

In this short review, we summarize how insights into the structure and dynamics of interferon-receptor complex assembly and activation guided the design of a novel class of engineered type I interferons that combine a largely lost potency on non-targeted cells with high activity on targeted cells. These novel interferons are expected to exhibit lower systemic toxicities compared to other interferon therapy modalities and could open avenues to revive these cytokines for the treatment of patients suffering of cancer and viral infections.

KEYWORDS:

Antibody; Immunocytokine; Interferon; Receptor

PMID:
25466630
DOI:
10.1016/j.cytogfr.2014.10.006
[Indexed for MEDLINE]

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