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Items: 1 to 20 of 430

1.

Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence.

Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE.

Pharmacol Res Perspect. 2018 Jun 19;6(4):e00403. doi: 10.1002/prp2.403. eCollection 2018 Jul.

2.

Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M.

Neurosci Lett. 2018 Apr 23;673:24-27. doi: 10.1016/j.neulet.2018.02.054. Epub 2018 Feb 25.

PMID:
29490230
3.

New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders.

Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP.

AAPS J. 2018 Feb 9;20(2):29. doi: 10.1208/s12248-018-0192-y.

PMID:
29427069
4.

A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells.

Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL.

Biochemistry. 2018 Feb 20;57(7):1262-1273. doi: 10.1021/acs.biochem.7b01176. Epub 2018 Jan 30.

PMID:
29345908
5.

Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy.

Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M.

Life Sci. 2018 Jan 1;192:151-159. doi: 10.1016/j.lfs.2017.11.042. Epub 2017 Nov 28.

PMID:
29191644
6.

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.

Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5467-5472. doi: 10.1016/j.bmcl.2017.10.039. Epub 2017 Oct 20.

PMID:
29153425
7.

Pharmacological Dual Inhibition of Tumor and Tumor-Induced Functional Limitations in a Transgenic Model of Breast Cancer.

Wang R, Bhat-Nakshatri P, Padua MB, Prasad MS, Anjanappa M, Jacobson M, Finnearty C, Sefcsik V, McElyea K, Redmond R, Sandusky G, Penthala N, Crooks PA, Liu J, Zimmers T, Nakshatri H.

Mol Cancer Ther. 2017 Dec;16(12):2747-2758. doi: 10.1158/1535-7163.MCT-17-0717. Epub 2017 Oct 4.

8.

Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats.

Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ.

Behav Pharmacol. 2018 Feb;29(1):87-97. doi: 10.1097/FBP.0000000000000340.

PMID:
28863003
9.

Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.

Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA, Prather PL.

Pharmacol Res. 2017 Nov;125(Pt B):161-177. doi: 10.1016/j.phrs.2017.08.008. Epub 2017 Aug 23.

PMID:
28838808
10.

DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo.

Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen-Williams IE, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH.

Free Radic Biol Med. 2017 Nov;112:318-326. doi: 10.1016/j.freeradbiomed.2017.08.001. Epub 2017 Aug 3.

PMID:
28782644
11.

Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl.

Walbaum A, Fifer EK, Parkin S, Crooks PA.

Acta Crystallogr E Crystallogr Commun. 2017 May 19;73(Pt 6):864-866. doi: 10.1107/S2056989017007277. eCollection 2017 Jun 1.

12.

Succinamide derivatives of melampomagnolide B and their anti-cancer activities.

Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA.

Bioorg Med Chem. 2017 Jul 15;25(14):3694-3705. doi: 10.1016/j.bmc.2017.05.008. Epub 2017 May 8.

PMID:
28545815
13.

Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.

Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA.

Eur J Med Chem. 2017 Aug 18;136:393-405. doi: 10.1016/j.ejmech.2017.05.031. Epub 2017 May 11.

PMID:
28525840
14.

Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats.

Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M.

Anesth Analg. 2017 Sep;125(3):1021-1031. doi: 10.1213/ANE.0000000000002006.

PMID:
28489639
15.

Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents.

Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujillo-Alonso V, Guzman ML, Crooks PA.

Anticancer Agents Med Chem. 2017 Apr 12. doi: 10.2174/1871521409666170412115703. [Epub ahead of print]

PMID:
28403783
16.

Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis.

Yadlapalli JSK, Albayati ZAF, Penthala NR, Hendrickson HP, Crooks PA.

Biomed Chromatogr. 2017 Sep;31(9). doi: 10.1002/bmc.3957. Epub 2017 Mar 24.

PMID:
28205234
17.

Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.

Albayati ZAF, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA.

Bioorg Med Chem. 2017 Feb 1;25(3):1235-1241. doi: 10.1016/j.bmc.2016.12.036. Epub 2016 Dec 26.

18.

GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.

Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP.

Eur J Pharmacol. 2017 Jan 15;795:143-149. doi: 10.1016/j.ejphar.2016.12.016. Epub 2016 Dec 13.

PMID:
27986625
19.

Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.

Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT.

J Biol Chem. 2016 Nov 25;291(48):25280. No abstract available.

20.

N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.

Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5883-5886. doi: 10.1016/j.bmcl.2016.11.015. Epub 2016 Nov 9.

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