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Items: 1 to 20 of 33


Properties of cell signaling pathways and gene expression systems operating far from steady-state.

Di-Bella JP, Colman-Lerner A, Ventura AC.

Sci Rep. 2018 Nov 19;8(1):17035. doi: 10.1038/s41598-018-34766-0.


Heat-stress triggers MAPK crosstalk to turn on the hyperosmotic response pathway.

Dunayevich P, Baltanás R, Clemente JA, Couto A, Sapochnik D, Vasen G, Colman-Lerner A.

Sci Rep. 2018 Oct 11;8(1):15168. doi: 10.1038/s41598-018-33203-6.


Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling.

Pesce CG, Zdraljevic S, Peria WJ, Bush A, Repetto MV, Rockwell D, Yu RC, Colman-Lerner A, Brent R.

Mol Syst Biol. 2018 Apr 4;14(4):e7390. doi: 10.15252/msb.20167390.


CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5.

Repetto MV, Winters MJ, Bush A, Reiter W, Hollenstein DM, Ammerer G, Pryciak PM, Colman-Lerner A.

Mol Cell. 2018 Mar 15;69(6):938-952.e6. doi: 10.1016/j.molcel.2018.02.018.


Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations.

Altszyler E, Ventura AC, Colman-Lerner A, Chernomoretz A.

PLoS One. 2017 Jun 29;12(6):e0180083. doi: 10.1371/journal.pone.0180083. eCollection 2017.


Yeast GPCR signaling reflects the fraction of occupied receptors, not the number.

Bush A, Vasen G, Constantinou A, Dunayevich P, Patop IL, Blaustein M, Colman-Lerner A.

Mol Syst Biol. 2016 Dec 29;12(12):898. doi: 10.15252/msb.20166910.


Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.

Andrews SS, Peria WJ, Yu RC, Colman-Lerner A, Brent R.

Cell Syst. 2016 Nov 23;3(5):444-455.e2. doi: 10.1016/j.cels.2016.10.002. Epub 2016 Oct 27.


Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it.

Karlsson M, Janzén DL, Durrieu L, Colman-Lerner A, Kjellsson MC, Cedersund G.

BMC Syst Biol. 2015 Sep 4;9:52. doi: 10.1186/s12918-015-0203-x.


Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.

Doncic A, Atay O, Valk E, Grande A, Bush A, Vasen G, Colman-Lerner A, Loog M, Skotheim JM.

Cell. 2015 Mar 12;160(6):1182-95. doi: 10.1016/j.cell.2015.02.032.


Impact of upstream and downstream constraints on a signaling module's ultrasensitivity.

Altszyler E, Ventura A, Colman-Lerner A, Chernomoretz A.

Phys Biol. 2014 Oct 14;11(6):066003. doi: 10.1088/1478-3975/11/6/066003.


Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range.

Ventura AC, Bush A, Vasen G, Goldín MA, Burkinshaw B, Bhattacharjee N, Folch A, Brent R, Chernomoretz A, Colman-Lerner A.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3860-9. doi: 10.1073/pnas.1322761111. Epub 2014 Aug 29.


Messages do diffuse faster than messengers: reconciling disparate estimates of the morphogen bicoid diffusion coefficient.

Sigaut L, Pearson JE, Colman-Lerner A, Ponce Dawson S.

PLoS Comput Biol. 2014 Jun 5;10(6):e1003629. doi: 10.1371/journal.pcbi.1003629. eCollection 2014 Jun.


Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle.

Risso G, Pelisch F, Pozzi B, Mammi P, Blaustein M, Colman-Lerner A, Srebrow A.

Cell Cycle. 2013 Oct 1;12(19):3165-74. doi: 10.4161/cc.26183. Epub 2013 Aug 27.


Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia.

Blaustein M, Pérez-Munizaga D, Sánchez MA, Urrutia C, Grande A, Risso G, Srebrow A, Alfaro J, Colman-Lerner A.

PLoS One. 2013 Jul 29;8(7):e69668. doi: 10.1371/journal.pone.0069668. Print 2013.


Pheromone-induced morphogenesis improves osmoadaptation capacity by activating the HOG MAPK pathway.

Baltanás R, Bush A, Couto A, Durrieu L, Hohmann S, Colman-Lerner A.

Sci Signal. 2013 Apr 23;6(272):ra26. doi: 10.1126/scisignal.2003312.


Quantitative measurement of protein relocalization in live cells.

Bush A, Colman-Lerner A.

Biophys J. 2013 Feb 5;104(3):727-36. doi: 10.1016/j.bpj.2012.12.030.


Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.

Schaber J, Baltanas R, Bush A, Klipp E, Colman-Lerner A.

Mol Syst Biol. 2012;8:622. doi: 10.1038/msb.2012.53.


Using Cell-ID 1.4 with R for microscope-based cytometry.

Bush A, Chernomoretz A, Yu R, Gordon A, Colman-Lerner A.

Curr Protoc Mol Biol. 2012 Oct;Chapter 14:Unit 14.18. doi: 10.1002/0471142727.mb1418s100.


PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer.

Riggio M, Polo ML, Blaustein M, Colman-Lerner A, Lüthy I, Lanari C, Novaro V.

Carcinogenesis. 2012 Mar;33(3):509-18. doi: 10.1093/carcin/bgr303. Epub 2011 Dec 17.


Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.

Thomson TM, Benjamin KR, Bush A, Love T, Pincus D, Resnekov O, Yu RC, Gordon A, Colman-Lerner A, Endy D, Brent R.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20265-70. doi: 10.1073/pnas.1004042108. Epub 2011 Nov 23.

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