Format

Send to

Choose Destination
Clin Pharmacol Ther. 2012 Oct;92(4):434-6. doi: 10.1038/clpt.2012.130. Epub 2012 Sep 5.

Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.

Author information

1
Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. sleeder@cmh.edu

Abstract

In a 2010 review in Clinical Pharmacology & Therapeutics, Nick Holford noted that in neonates and young infants, maturation of the organs responsible for drug clearance is a more important determinant of pharmacokinetics (PK) than is body size.(1) Here we review recent developments that provide new insights into how physiological and environmental changes associated with adaptation to extrauterine life affect the ontogeny of drug biotransformation and interpretation of genotype-phenotype relationships in newborns and infants.

PMID:
22948896
DOI:
10.1038/clpt.2012.130
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center