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Items: 1 to 20 of 33


The Tomato Nucleotide-binding Leucine-rich Repeat Immune Receptor I-2 Couples DNA-binding to Nucleotide-binding Domain Nucleotide Exchange.

Fenyk S, Dixon CH, Gittens WH, Townsend PD, Sharples GJ, Pålsson LO, Takken FL, Cann MJ.

J Biol Chem. 2016 Jan 15;291(3):1137-47. doi: 10.1074/jbc.M115.698589.


Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.

Turner MJ, Saint-Criq V, Patel W, Ibrahim SH, Verdon B, Ward C, Garnett JP, Tarran R, Cann MJ, Gray MA.

J Physiol. 2016 Mar 15;594(6):1643-61. doi: 10.1113/JP271309.


Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?

McLeish TC, Cann MJ, Rodgers TL.

Biophys J. 2015 Sep 15;109(6):1240-50. doi: 10.1016/j.bpj.2015.08.009.


The Potato Nucleotide-binding Leucine-rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-dependent DNA-deforming Protein.

Fenyk S, Townsend PD, Dixon CH, Spies GB, de San Eustaquio Campillo A, Slootweg EJ, Westerhof LB, Gawehns FK, Knight MR, Sharples GJ, Goverse A, Pålsson LO, Takken FL, Cann MJ.

J Biol Chem. 2015 Oct 9;290(41):24945-60. doi: 10.1074/jbc.M115.672121.


The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein.

Townsend PD, Rodgers TL, Glover LC, Korhonen HJ, Richards SA, Colwell LJ, Pohl E, Wilson MR, Hodgson DR, McLeish TC, Cann MJ.

J Biol Chem. 2015 Sep 4;290(36):22225-35. doi: 10.1074/jbc.M115.669267.


Global low-frequency motions in protein allostery: CAP as a model system.

Townsend PD, Rodgers TL, Pohl E, Wilson MR, McLeish TC, Cann MJ.

Biophys Rev. 2015;7(2):175-182.


The crystal structures of apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors.

Townsend PD, Jungwirth B, Pojer F, Bußmann M, Money VA, Cole ST, Pühler A, Tauch A, Bott M, Cann MJ, Pohl E.

PLoS One. 2014 Dec 3;9(12):e113265. doi: 10.1371/journal.pone.0113265.


CO₂directly modulates connexin 26 by formation of carbamate bridges between subunits.

Meigh L, Greenhalgh SA, Rodgers TL, Cann MJ, Roper DI, Dale N.

Elife. 2013 Nov 12;2:e01213. doi: 10.7554/eLife.01213.


Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.

Rodgers TL, Townsend PD, Burnell D, Jones ML, Richards SA, McLeish TC, Pohl E, Wilson MR, Cann MJ.

PLoS Biol. 2013 Sep;11(9):e1001651. doi: 10.1371/journal.pbio.1001651.


ΔΔPT: a comprehensive toolbox for the analysis of protein motion.

Rodgers TL, Burnell D, Townsend PD, Pohl E, Cann MJ, Wilson MR, McLeish TC.

BMC Bioinformatics. 2013 Jun 7;14:183. doi: 10.1186/1471-2105-14-183.


Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors.

Nunes AR, Holmes AP, Sample V, Kumar P, Cann MJ, Monteiro EC, Zhang J, Gauda EB.

Respir Physiol Neurobiol. 2013 Aug 15;188(2):83-93. doi: 10.1016/j.resp.2013.05.013.


Elevated carbon dioxide blunts mammalian cAMP signaling dependent on inositol 1,4,5-triphosphate receptor-mediated Ca2+ release.

Cook ZC, Gray MA, Cann MJ.

J Biol Chem. 2012 Jul 27;287(31):26291-301. doi: 10.1074/jbc.M112.349191.


Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.

J Mol Biol. 2012 Feb 17;416(2):271-86. doi: 10.1016/j.jmb.2011.12.045.


A nucleotide phosphatase activity in the nucleotide binding domain of an orphan resistance protein from rice.

Fenyk S, Campillo Ade S, Pohl E, Hussey PJ, Cann MJ.

J Biol Chem. 2012 Feb 3;287(6):4023-32. doi: 10.1074/jbc.M111.314450.


The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity.

Fulcher NB, Holliday PM, Klem E, Cann MJ, Wolfgang MC.

Mol Microbiol. 2010 May;76(4):889-904. doi: 10.1111/j.1365-2958.2010.07135.x.


Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.

Townsend PD, Holliday PM, Fenyk S, Hess KC, Gray MA, Hodgson DR, Cann MJ.

J Biol Chem. 2009 Jan 9;284(2):784-91. doi: 10.1074/jbc.M807239200.


Sodium regulation of GAF domain function.

Cann MJ.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1032-4. Review.


Regulation of prokaryotic adenylyl cyclases by CO2.

Hammer A, Hodgson DR, Cann MJ.

Biochem J. 2006 Jun 1;396(2):215-8.

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