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Items: 1 to 20 of 43


Adult-onset hepatocyte GH resistance promotes NASH in male mice, without severe systemic metabolic dysfunction.

Cordoba-Chacon J, Sarmento-Cabral A, Del Rio-Moreno M, Diaz-Ruiz A, Subbaiah PV, Kineman RD.

Endocrinology. 2018 Oct 5. doi: 10.1210/en.2018-00669. [Epub ahead of print]


Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity.

Yamamoto S, Kuramoto K, Wang N, Situ X, Priyadarshini M, Zhang W, Cordoba-Chacon J, Layden BT, He C.

Cell Rep. 2018 Jun 12;23(11):3286-3299. doi: 10.1016/j.celrep.2018.05.032.


Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP.

Sci Rep. 2016 Nov 30;6:37992. doi: 10.1038/srep37992.


Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice.

Wolf Greenstein A, Majumdar N, Yang P, Subbaiah PV, Kineman RD, Cordoba-Chacon J.

J Endocrinol. 2017 Jan;232(1):107-121. Epub 2016 Oct 31.


Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.


Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

Villa-Osaba A, Gahete MD, Cordoba-Chacon J, de Lecea L, Castaño JP, Luque RM.

Mol Cell Endocrinol. 2016 Oct 15;434:14-24. doi: 10.1016/j.mce.2016.06.014. Epub 2016 Jun 9.


Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.

Cordoba-Chacón J, Gahete MD, Pozo-Salas AI, de Lecea L, Castaño JP, Luque RM.

Endocrinology. 2016 Jul;157(7):2810-23. doi: 10.1210/en.2016-1195. Epub 2016 May 13.


Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice.

Kineman RD, Majumdar N, Subbaiah PV, Cordoba-Chacon J.

Endocrinology. 2016 May;157(5):1728-35. doi: 10.1210/en.2015-2077. Epub 2016 Mar 7.


Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.

Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.


Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

Cordoba-Chacon J, Majumdar N, Pokala NK, Gahete MD, Kineman RD.

Growth Horm IGF Res. 2015 Aug;25(4):189-95. doi: 10.1016/j.ghir.2015.04.002. Epub 2015 Apr 17.


Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels.

Pedraza-Arévalo S, Córdoba-Chacón J, Pozo-Salas AI, L-López F, de Lecea L, Gahete MD, Castaño JP, Luque RM.

Endocrinology. 2015 Jun;156(6):1958-64. doi: 10.1210/en.2015-1132. Epub 2015 Apr 1.


Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.

Villa-Osaba A, Gahete MD, Córdoba-Chacón J, de Lecea L, Pozo-Salas AI, Delgado-Lista FJ, Álvarez-Benito M, López-Miranda J, Luque RM, Castaño JP.

PLoS One. 2015 Mar 25;10(3):e0120955. doi: 10.1371/journal.pone.0120955. eCollection 2015.


Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates.

Ibáñez-Costa A, Córdoba-Chacón J, Gahete MD, Kineman RD, Castaño JP, Luque RM.

Endocrinology. 2015 Mar;156(3):1100-10. doi: 10.1210/en.2014-1819. Epub 2014 Dec 29.


Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Cordoba-Chacon J, Gahete MD, McGuinness OP, Kineman RD.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.


Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice.

Gahete MD, Córdoba-Chacón J, Lantvit DD, Ortega-Salas R, Sanchez-Sanchez R, Pérez-Jiménez F, López-Miranda J, Swanson SM, Castaño JP, Luque RM, Kineman RD.

Carcinogenesis. 2014 Nov;35(11):2467-73. doi: 10.1093/carcin/bgu161. Epub 2014 Aug 1.


Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Luque RM, Córdoba-Chacón J, Ibáñez-Costa A, Gesmundo I, Grande C, Gracia-Navarro F, Tena-Sempere M, Ghigo E, Gahete MD, Granata R, Kineman RD, Castaño JP.

Endocrinology. 2014 Apr;155(4):1407-17. doi: 10.1210/en.2013-1728. Epub 2014 Jan 31.


Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

Cordoba-Chacon J, Gahete MD, Pokala NK, Geldermann D, Alba M, Salvatori R, Luque RM, Kineman RD.

Endocrinology. 2014 Mar;155(3):726-35. doi: 10.1210/en.2013-1825. Epub 2013 Dec 16.


Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Kineman RD, Luque RM.

Endocrinology. 2013 Jul;154(7):2393-8. doi: 10.1210/en.2013-1136. Epub 2013 May 21.


Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Gahete MD, Córdoba-Chacón J, Lin Q, Brüning JC, Kahn CR, Castaño JP, Christian H, Luque RM, Kineman RD.

Endocrinology. 2013 Jul;154(7):2410-20. doi: 10.1210/en.2013-1261. Epub 2013 May 13.


Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions.

Chanclón B, Luque RM, Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Gracia-Navarro F, Martínez-Fuentes AJ.

PLoS One. 2013;8(2):e57834. doi: 10.1371/journal.pone.0057834. Epub 2013 Feb 28.

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