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Items: 1 to 20 of 43

1.

Adult-onset hepatocyte GH resistance promotes NASH in male mice, without severe systemic metabolic dysfunction.

Cordoba-Chacon J, Sarmento-Cabral A, Del Rio-Moreno M, Diaz-Ruiz A, Subbaiah PV, Kineman RD.

Endocrinology. 2018 Oct 5. doi: 10.1210/en.2018-00669. [Epub ahead of print]

PMID:
30295789
2.

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity.

Yamamoto S, Kuramoto K, Wang N, Situ X, Priyadarshini M, Zhang W, Cordoba-Chacon J, Layden BT, He C.

Cell Rep. 2018 Jun 12;23(11):3286-3299. doi: 10.1016/j.celrep.2018.05.032.

3.

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP.

Sci Rep. 2016 Nov 30;6:37992. doi: 10.1038/srep37992.

4.

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice.

Wolf Greenstein A, Majumdar N, Yang P, Subbaiah PV, Kineman RD, Cordoba-Chacon J.

J Endocrinol. 2017 Jan;232(1):107-121. Epub 2016 Oct 31.

5.

Growth Hormone Control of Hepatic Lipid Metabolism.

Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S.

Diabetes. 2016 Dec;65(12):3598-3609. Epub 2016 Sep 27.

6.

Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

Villa-Osaba A, Gahete MD, Cordoba-Chacon J, de Lecea L, Castaño JP, Luque RM.

Mol Cell Endocrinol. 2016 Oct 15;434:14-24. doi: 10.1016/j.mce.2016.06.014. Epub 2016 Jun 9.

PMID:
27291340
7.

Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.

Cordoba-Chacón J, Gahete MD, Pozo-Salas AI, de Lecea L, Castaño JP, Luque RM.

Endocrinology. 2016 Jul;157(7):2810-23. doi: 10.1210/en.2016-1195. Epub 2016 May 13.

PMID:
27175972
8.

Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice.

Kineman RD, Majumdar N, Subbaiah PV, Cordoba-Chacon J.

Endocrinology. 2016 May;157(5):1728-35. doi: 10.1210/en.2015-2077. Epub 2016 Mar 7.

9.

Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.

Cordoba-Chacon J, Majumdar N, List EO, Diaz-Ruiz A, Frank SJ, Manzano A, Bartrons R, Puchowicz M, Kopchick JJ, Kineman RD.

Diabetes. 2015 Sep;64(9):3093-103. doi: 10.2337/db15-0370. Epub 2015 May 26.

10.

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.

Cordoba-Chacon J, Majumdar N, Pokala NK, Gahete MD, Kineman RD.

Growth Horm IGF Res. 2015 Aug;25(4):189-95. doi: 10.1016/j.ghir.2015.04.002. Epub 2015 Apr 17.

PMID:
25936582
11.

Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels.

Pedraza-Arévalo S, Córdoba-Chacón J, Pozo-Salas AI, L-López F, de Lecea L, Gahete MD, Castaño JP, Luque RM.

Endocrinology. 2015 Jun;156(6):1958-64. doi: 10.1210/en.2015-1132. Epub 2015 Apr 1.

PMID:
25830706
12.

Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.

Villa-Osaba A, Gahete MD, Córdoba-Chacón J, de Lecea L, Pozo-Salas AI, Delgado-Lista FJ, Álvarez-Benito M, López-Miranda J, Luque RM, Castaño JP.

PLoS One. 2015 Mar 25;10(3):e0120955. doi: 10.1371/journal.pone.0120955. eCollection 2015.

13.

Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates.

Ibáñez-Costa A, Córdoba-Chacón J, Gahete MD, Kineman RD, Castaño JP, Luque RM.

Endocrinology. 2015 Mar;156(3):1100-10. doi: 10.1210/en.2014-1819. Epub 2014 Dec 29.

14.

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice.

Cordoba-Chacon J, Gahete MD, McGuinness OP, Kineman RD.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E928-34. doi: 10.1152/ajpendo.00420.2014. Epub 2014 Sep 30.

15.

Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice.

Gahete MD, Córdoba-Chacón J, Lantvit DD, Ortega-Salas R, Sanchez-Sanchez R, Pérez-Jiménez F, López-Miranda J, Swanson SM, Castaño JP, Luque RM, Kineman RD.

Carcinogenesis. 2014 Nov;35(11):2467-73. doi: 10.1093/carcin/bgu161. Epub 2014 Aug 1.

16.

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Luque RM, Córdoba-Chacón J, Ibáñez-Costa A, Gesmundo I, Grande C, Gracia-Navarro F, Tena-Sempere M, Ghigo E, Gahete MD, Granata R, Kineman RD, Castaño JP.

Endocrinology. 2014 Apr;155(4):1407-17. doi: 10.1210/en.2013-1728. Epub 2014 Jan 31.

17.

Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.

Cordoba-Chacon J, Gahete MD, Pokala NK, Geldermann D, Alba M, Salvatori R, Luque RM, Kineman RD.

Endocrinology. 2014 Mar;155(3):726-35. doi: 10.1210/en.2013-1825. Epub 2013 Dec 16.

18.

Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.

Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Kineman RD, Luque RM.

Endocrinology. 2013 Jul;154(7):2393-8. doi: 10.1210/en.2013-1136. Epub 2013 May 21.

19.

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Gahete MD, Córdoba-Chacón J, Lin Q, Brüning JC, Kahn CR, Castaño JP, Christian H, Luque RM, Kineman RD.

Endocrinology. 2013 Jul;154(7):2410-20. doi: 10.1210/en.2013-1261. Epub 2013 May 13.

20.

Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions.

Chanclón B, Luque RM, Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Castaño JP, Gracia-Navarro F, Martínez-Fuentes AJ.

PLoS One. 2013;8(2):e57834. doi: 10.1371/journal.pone.0057834. Epub 2013 Feb 28.

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