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Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells.

Koh W, Gonzalez V, Natarajan S, Carter R, Brown PO, Gawad C.

PLoS One. 2016 Oct 13;11(10):e0164085. doi: 10.1371/journal.pone.0164085. eCollection 2016.


Directed Chemical Evolution with an Outsized Genetic Code.

Krusemark CJ, Tilmans NP, Brown PO, Harbury PB.

PLoS One. 2016 Aug 10;11(8):e0154765. doi: 10.1371/journal.pone.0154765. eCollection 2016.


Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets.

Hogan GJ, Brown PO, Herschlag D.

PLoS Biol. 2015 Nov 20;13(11):e1002307. doi: 10.1371/journal.pbio.1002307. eCollection 2015.


Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling.

Riordan DP, Varma S, West RB, Brown PO.

PLoS One. 2015 Jul 15;10(7):e0128975. doi: 10.1371/journal.pone.0128975. eCollection 2015.


miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway.

Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar SS, Lam JS, Qian D, Dirbas FM, Somlo G, Lao K, Brown PO, Clarke MF, Shimono Y.

Elife. 2014 Nov 18;3. doi: 10.7554/eLife.01977.


Transcriptome-wide mapping of pseudouridines: pseudouridine synthases modify specific mRNAs in S. cerevisiae.

Lovejoy AF, Riordan DP, Brown PO.

PLoS One. 2014 Oct 29;9(10):e110799. doi: 10.1371/journal.pone.0110799. eCollection 2014.


Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments.

Lareau LF, Hite DH, Hogan GJ, Brown PO.

Elife. 2014 May 9;3:e01257. doi: 10.7554/eLife.01257.


Circular RNA is expressed across the eukaryotic tree of life.

Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J.

PLoS One. 2014 Mar 7;9(6):e90859. doi: 10.1371/journal.pone.0090859. eCollection 2014. Erratum in: PLoS One. 2014;9(4):e95116.


Cell-type specific features of circular RNA expression.

Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO.

PLoS Genet. 2013;9(9):e1003777. doi: 10.1371/journal.pgen.1003777. Epub 2013 Sep 5. Erratum in: PLoS Genet. 2013 Dec;9(12). doi:10.1371/annotation/f782282b-eefa-4c8d-985c-b1484e845855.


Quantitative proteomic analysis reveals concurrent RNA-protein interactions and identifies new RNA-binding proteins in Saccharomyces cerevisiae.

Klass DM, Scheibe M, Butter F, Hogan GJ, Mann M, Brown PO.

Genome Res. 2013 Jun;23(6):1028-38. doi: 10.1101/gr.153031.112. Epub 2013 May 1.


An interview with Patrick O Brown on the origins and future of open access.

Brown PO.

BMC Biol. 2013 Apr 15;11:33. doi: 10.1186/1741-7007-11-33. No abstract available.


Improved discovery of molecular interactions in genome-scale data with adaptive model-based normalization.

Salzman J, Klass DM, Brown PO.

PLoS One. 2013;8(1):e53930. doi: 10.1371/journal.pone.0053930. Epub 2013 Jan 22.


The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA.

Tsvetanova NG, Riordan DP, Brown PO.

PLoS Genet. 2012;8(7):e1002862. doi: 10.1371/journal.pgen.1002862. Epub 2012 Jul 26.


Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformation.

Bates JG, Salzman J, May D, Garcia PB, Hogan GJ, McIntosh M, Schlissel MS, Brown PO.

PLoS One. 2012;7(5):e37108. doi: 10.1371/journal.pone.0037108. Epub 2012 May 31.


Widespread mRNA association with cytoskeletal motor proteins and identification and dynamics of myosin-associated mRNAs in S. cerevisiae.

Casolari JM, Thompson MA, Salzman J, Champion LM, Moerner WE, Brown PO.

PLoS One. 2012;7(2):e31912. doi: 10.1371/journal.pone.0031912. Epub 2012 Feb 16.


Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.

Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO.

PLoS One. 2012;7(2):e30733. doi: 10.1371/journal.pone.0030733. Epub 2012 Feb 1.


ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma.

Salzman J, Marinelli RJ, Wang PL, Green AE, Nielsen JS, Nelson BH, Drescher CW, Brown PO.

PLoS Biol. 2011 Sep;9(9):e1001156. doi: 10.1371/journal.pbio.1001156. Epub 2011 Sep 20.


Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.

del Alamo M, Hogan DJ, Pechmann S, Albanese V, Brown PO, Frydman J.

PLoS Biol. 2011 Jul;9(7):e1001100. doi: 10.1371/journal.pbio.1001100. Epub 2011 Jul 12.



Brown PO.

In: Coffin JM, Hughes SH, Varmus HE, editors. Retroviruses. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.


Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus.

Rubins KH, Hensley LE, Relman DA, Brown PO.

PLoS One. 2011 Jan 18;6(1):e15615. doi: 10.1371/journal.pone.0015615.

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