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Items: 1 to 20 of 350

1.

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

van den Berg LH, Sorenson E, Gronseth G, Macklin EA, Andrews J, Baloh RH, Benatar M, Berry JD, Chio A, Corcia P, Genge A, Gubitz AK, Lomen-Hoerth C, McDermott CJ, Pioro EP, Rosenfeld J, Silani V, Turner MR, Weber M, Brooks BR, Miller RG, Mitsumoto H; Airlie House ALS Clinical Trials Guidelines Group.

Neurology. 2019 Mar 8. pii: 10.1212/WNL.0000000000007242. doi: 10.1212/WNL.0000000000007242. [Epub ahead of print]

PMID:
30850440
2.

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyotrophic lateral sclerosis.

Pattee GL, Plowman EK, Focht Garand KL, Costello J, Brooks BR, Berry JD, Smith RA, Atassi N, Chapin JL, Yunusova Y, McIlduff CE, Young E, Macklin EA, Locatelli ER, Silani V, Heitzman D, Wymer J, Goutman SA, Gelinas DF, Perry B, Nalipinski P, Stipancic K, O'Brien M, Sullivan SL, Pioro EP, Gargiulo G, Green JR; Contributing Members of the NEALS Bulbar Subcommittee.

Muscle Nerve. 2019 Jan 8. doi: 10.1002/mus.26408. [Epub ahead of print]

PMID:
30620104
3.

On the convergence of multi-scale free energy simulations.

König G, Brooks BR, Thiel W, York DM.

Mol Simul. 2018;44(13-14):1062-1081. doi: 10.1080/08927022.2018.1475741. Epub 2018 May 30.

PMID:
30581251
4.

A Comparison of QM/MM Simulations with and without the Drude Oscillator Model Based on Hydration Free Energies of Simple Solutes.

König G, Pickard FC, Huang J, Thiel W, MacKerell AD, Brooks BR, York DM.

Molecules. 2018 Oct 19;23(10). pii: E2695. doi: 10.3390/molecules23102695.

5.

Amyloid Fibril Design: Limiting Structural Polymorphism in Alzheimer's Aβ Protofilaments.

Tywoniuk B, Yuan Y, McCartan S, Szydłowska BM, Tofoleanu F, Brooks BR, Buchete NV.

J Phys Chem B. 2018 Nov 29. doi: 10.1021/acs.jpcb.8b07423. [Epub ahead of print]

PMID:
30335383
6.

Comparison of the umbrella sampling and the double decoupling method in binding free energy predictions for SAMPL6 octa-acid host-guest challenges.

Nishikawa N, Han K, Wu X, Tofoleanu F, Brooks BR.

J Comput Aided Mol Des. 2018 Oct;32(10):1075-1086. doi: 10.1007/s10822-018-0166-2. Epub 2018 Oct 15.

7.

An explicit-solvent hybrid QM and MM approach for predicting pKa of small molecules in SAMPL6 challenge.

Prasad S, Huang J, Zeng Q, Brooks BR.

J Comput Aided Mol Des. 2018 Oct;32(10):1191-1201. doi: 10.1007/s10822-018-0167-1. Epub 2018 Oct 1.

PMID:
30276503
8.

Force matching as a stepping stone to QM/MM CB[8] host/guest binding free energies: a SAMPL6 cautionary tale.

Hudson PS, Han K, Woodcock HL, Brooks BR.

J Comput Aided Mol Des. 2018 Oct;32(10):983-999. doi: 10.1007/s10822-018-0165-3. Epub 2018 Oct 1.

PMID:
30276502
9.

Conformational analysis of replica exchange MD: Temperature-dependent Markov networks for FF amyloid peptides.

Narayan B, Herbert C, Yuan Y, Rodriguez BJ, Brooks BR, Buchete NV.

J Chem Phys. 2018 Aug 21;149(7):072323. doi: 10.1063/1.5027580.

PMID:
30134732
10.

Reservoir pH replica exchange.

Damjanovic A, Miller BT, Okur A, Brooks BR.

J Chem Phys. 2018 Aug 21;149(7):072321. doi: 10.1063/1.5027413.

PMID:
30134701
11.

Absolute and relative pKa predictions via a DFT approach applied to the SAMPL6 blind challenge.

Zeng Q, Jones MR, Brooks BR.

J Comput Aided Mol Des. 2018 Oct;32(10):1179-1189. doi: 10.1007/s10822-018-0150-x. Epub 2018 Aug 20.

PMID:
30128926
12.

Prediction of CB[8] host-guest binding free energies in SAMPL6 using the double-decoupling method.

Han K, Hudson PS, Jones MR, Nishikawa N, Tofoleanu F, Brooks BR.

J Comput Aided Mol Des. 2018 Oct;32(10):1059-1073. doi: 10.1007/s10822-018-0144-8. Epub 2018 Aug 6.

PMID:
30084077
13.

Stage of prolonged survival in ALS.

Brooks BR, Bravver EK, Langford VL, Bockenek WL, Lindblom SS.

Lancet Neurol. 2018 Jul;17(7):579. doi: 10.1016/S1474-4422(18)30207-2. No abstract available.

PMID:
29914701
14.

Hydronium Ions Accompanying Buried Acidic Residues Lead to High Apparent Dielectric Constants in the Interior of Proteins.

Wu X, Brooks BR.

J Phys Chem B. 2018 Jun 14;122(23):6215-6223. doi: 10.1021/acs.jpcb.8b04584. Epub 2018 Jun 1.

15.

Edaravone in the treatment of amyotrophic lateral sclerosis: efficacy and access to therapy - a roundtable discussion.

Brooks BR, Jorgenson JA, Newhouse BJ, Shefner JM, Agnese W.

Am J Manag Care. 2018 Apr;24(9 Suppl):S175-S186.

16.

Structural Modulation of Human Amylin Protofilaments by Naturally Occurring Mutations.

Tofoleanu F, Yuan Y, Pickard FC 4th, Tywoniuk B, Brooks BR, Buchete NV.

J Phys Chem B. 2018 May 31;122(21):5657-5665. doi: 10.1021/acs.jpcb.7b12083. Epub 2018 Feb 21.

PMID:
29406755
17.

Comparison of Additive and Polarizable Models with Explicit Treatment of Long-Range Lennard-Jones Interactions Using Alkane Simulations.

Leonard AN, Simmonett AC, Pickard FC 4th, Huang J, Venable RM, Klauda JB, Brooks BR, Pastor RW.

J Chem Theory Comput. 2018 Feb 13;14(2):948-958. doi: 10.1021/acs.jctc.7b00948. Epub 2018 Jan 9.

18.

Best practices protocol for the evaluation of bulbar dysfunction: summary recommendations from the NEALS bulbar subcommittee symposium.

Pattee GL, Plowman EK, Brooks BR, Berry JD, Atassi N, Chapin JL, Garand K, Yunusova Y, Mcilduff CE, Young E, Costello JM, Macklin EA, Locatelli ER, Silani V, Heitzman D, Wymer J, Goutman SA, Gelinas DF, Smith R, Perry B, Nalipinski P, Stipancic K, O'Brien M, Sullivan SL, Green J; CONTRIBUTING MEMBERS OF THE NEALS BULBAR SUBCOMMITTEE.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):311-312. doi: 10.1080/21678421.2017.1404109. Epub 2017 Dec 5.

PMID:
29205054
19.

A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis.

Clawson LL, Cudkowicz M, Krivickas L, Brooks BR, Sanjak M, Allred P, Atassi N, Swartz A, Steinhorn G, Uchil A, Riley KM, Yu H, Schoenfeld DA, Maragakis NJ; neals consortium.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):250-258. doi: 10.1080/21678421.2017.1404108. Epub 2017 Nov 30.

PMID:
29191052
20.

Implementation of a Regional Training Program on African Swine Fever As Part of the Cooperative Biological Engagement Program across the Caucasus Region.

De Nardi M, Léger A, Stepanyan T, Khachatryan B, Karibayev T, Sytnik I, Tyulegenov S, Akhmetova A, Nychyk S, Sytiuk M, Nevolko O, Datsenko R, Chaligava T, Avaliani L, Parkadze O, Ninidze L, Kartskhia N, Napetvaridze T, Asanishvili Z, Khelaia D, Menteshashvili I, Zadayan M, Niazyan L, Mykhaylovska N, Brooks BR, Zhumabayeva G, Satabayeva S, Metreveli M, Gallagher T, Obiso R.

Front Vet Sci. 2017 Oct 26;4:164. doi: 10.3389/fvets.2017.00164. eCollection 2017.

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