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Items: 19


A Balanced Proinflammatory and Regulatory Cytokine Signature in Young African Children Is Associated With Lower Risk of Clinical Malaria.

Dobaño C, Nhabomba AJ, Manaca MN, Berthoud T, Aguilar R, Quintó L, Barbosa A, Rodríguez MH, Jiménez A, Groves PL, Santano R, Bassat Q, Aponte JJ, Guinovart C, Doolan DL, Alonso PL.

Clin Infect Dis. 2019 Aug 16;69(5):820-828. doi: 10.1093/cid/ciy934.


High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection.

Dobaño C, Berthoud T, Manaca MN, Nhabomba A, Guinovart C, Aguilar R, Barbosa A, Groves P, Rodríguez MH, Jimenez A, Quimice LM, Aponte JJ, Ordi J, Doolan DL, Mayor A, Alonso PL.

Malar J. 2018 May 10;17(1):177. doi: 10.1186/s12936-018-2317-2.


Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.

Dunachie S, Berthoud T, Hill AV, Fletcher HA.

Vaccine. 2015 Sep 29;33(40):5321-31. doi: 10.1016/j.vaccine.2015.07.087. Epub 2015 Aug 7.


MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy.

Dunachie SJ, Berthoud T, Keating SM, Hill AV, Fletcher HA.

PLoS One. 2010 Sep 3;5(9):e12557. doi: 10.1371/journal.pone.0012557.


Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses.

Reyes-Sandoval A, Berthoud T, Alder N, Siani L, Gilbert SC, Nicosia A, Colloca S, Cortese R, Hill AV.

Infect Immun. 2010 Jan;78(1):145-53. doi: 10.1128/IAI.00740-09. Epub 2009 Oct 26. Erratum in: Infect Immun. 2011 May;79(5):2131.


The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming.

Todryk SM, Pathan AA, Keating S, Porter DW, Berthoud T, Thompson F, Klenerman P, Hill AV.

Immunology. 2009 Sep;128(1):83-91. doi: 10.1111/j.1365-2567.2009.03073.x. Erratum in: Immunology. 2011 Apr;132(4):589.


Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.

Reyes-Sandoval A, Sridhar S, Berthoud T, Moore AC, Harty JT, Gilbert SC, Gao G, Ertl HC, Wilson JC, Hill AV.

Eur J Immunol. 2008 Mar;38(3):732-41. doi: 10.1002/eji.200737672. Erratum in: Eur J Immunol. 2011 May;41(5):1501.


Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial.

Thompson FM, Porter DW, Okitsu SL, Westerfeld N, Vogel D, Todryk S, Poulton I, Correa S, Hutchings C, Berthoud T, Dunachie S, Andrews L, Williams JL, Sinden R, Gilbert SC, Pluschke G, Zurbriggen R, Hill AV.

PLoS One. 2008 Jan 30;3(1):e1493. doi: 10.1371/journal.pone.0001493. Erratum in: PLoS One. 2011;6(2). doi: 10.1371/annotation/419b2f36-d46f-4f8a-8ffb-7fd2bfb33aa6.


Low-level malaria infections detected by a sensitive polymerase chain reaction assay and use of this technique in the evaluation of malaria vaccines in an endemic area.

Imoukhuede EB, Andrews L, Milligan P, Berthoud T, Bojang K, Nwakanma D, Ismaili J, Buckee C, Njie F, Keita S, Sowe M, Lang T, Gilbert SC, Greenwood BM, Hill AV.

Am J Trop Med Hyg. 2007 Mar;76(3):486-93.


A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

Dunachie SJ, Walther M, Epstein JE, Keating S, Berthoud T, Andrews L, Andersen RF, Bejon P, Goonetilleke N, Poulton I, Webster DP, Butcher G, Watkins K, Sinden RE, Levine GL, Richie TL, Schneider J, Kaslow D, Gilbert SC, Carucci DJ, Hill AV.

Infect Immun. 2006 Oct;74(10):5933-42.


Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.

Bejon P, Keating S, Mwacharo J, Kai OK, Dunachie S, Walther M, Berthoud T, Lang T, Epstein J, Carucci D, Moris P, Cohen J, Gilbert SC, Peshu N, Marsh K, Hill AV.

Infect Immun. 2006 Nov;74(11):6331-8. Epub 2006 Sep 11.


Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men.

Imoukhuede EB, Berthoud T, Milligan P, Bojang K, Ismaili J, Keating S, Nwakanma D, Keita S, Njie F, Sowe M, Todryk S, Laidlaw SM, Skinner MA, Lang T, Gilbert S, Greenwood BM, Hill AV.

Vaccine. 2006 Oct 30;24(42-43):6526-33. Epub 2006 Jun 28.


Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein.

Walther M, Thompson FM, Dunachie S, Keating S, Todryk S, Berthoud T, Andrews L, Andersen RF, Moore A, Gilbert SC, Poulton I, Dubovsky F, Tierney E, Correa S, Huntcooke A, Butcher G, Williams J, Sinden RE, Hill AV.

Infect Immun. 2006 May;74(5):2706-16.


A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.

Dunachie SJ, Walther M, Vuola JM, Webster DP, Keating SM, Berthoud T, Andrews L, Bejon P, Poulton I, Butcher G, Watkins K, Sinden RE, Leach A, Moris P, Tornieporth N, Schneider J, Dubovsky F, Tierney E, Williams J, Heppner DG Jr, Gilbert SC, Cohen J, Hill AV.

Vaccine. 2006 Apr 5;24(15):2850-9. Epub 2006 Jan 6.


Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria.

Keating SM, Bejon P, Berthoud T, Vuola JM, Todryk S, Webster DP, Dunachie SJ, Moorthy VS, McConkey SJ, Gilbert SC, Hill AV.

J Immunol. 2005 Nov 1;175(9):5675-80.


Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis.

Gilbert SC, Moorthy VS, Andrews L, Pathan AA, McConkey SJ, Vuola JM, Keating SM, Berthoud T, Webster D, McShane H, Hill AV.

Vaccine. 2006 May 22;24(21):4554-61. Epub 2005 Aug 24. Review.


Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara.

Webster DP, Dunachie S, Vuola JM, Berthoud T, Keating S, Laidlaw SM, McConkey SJ, Poulton I, Andrews L, Andersen RF, Bejon P, Butcher G, Sinden R, Skinner MA, Gilbert SC, Hill AV.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4836-41. Epub 2005 Mar 21.


Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers.

Vuola JM, Keating S, Webster DP, Berthoud T, Dunachie S, Gilbert SC, Hill AV.

J Immunol. 2005 Jan 1;174(1):449-55.


Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.

Walther M, Dunachie S, Keating S, Vuola JM, Berthoud T, Schmidt A, Maier C, Andrews L, Andersen RF, Gilbert S, Poulton I, Webster D, Dubovsky F, Tierney E, Sarpotdar P, Correa S, Huntcooke A, Butcher G, Williams J, Sinden RE, Thornton GB, Hill AV.

Vaccine. 2005 Jan 4;23(7):857-64.


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