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Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

Barrett JS, Spitsin S, Moorthy G, Barrett K, Baker K, Lackner A, Tulic F, Winters A, Evans DL, Douglas SD.

J Transl Med. 2016 May 26;14(1):148. doi: 10.1186/s12967-016-0904-y.


Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.

Mulugeta Y, Barrett JS, Nelson R, Eshete AT, Mushtaq A, Yao L, Glasgow N, Mulberg AE, Gonzalez D, Green D, Florian J, Krudys K, Seo S, Kim I, Chilukuri D, Burckart GJ.

J Clin Pharmacol. 2016 Nov;56(11):1326-1334. doi: 10.1002/jcph.744.


Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens.

Stockmann C, Barrett JS, Roberts JK, Sherwin C.

CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):630-40. doi: 10.1002/psp4.12038. Epub 2015 Nov 13.


A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children.

Barrett JS, Hirankarn S, Holford N, Hammer GB, Drover DR, Cohane CA, Anderson B, Dombrowski E, Reece T, Zajicek A, Schulman SR.

Front Pharmacol. 2015 Jul 28;6:151. doi: 10.3389/fphar.2015.00151. eCollection 2015.


Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.

Drover DR, Hammer GB, Barrett JS, Cohane CA, Reece T, Zajicek A, Schulman SR.

Front Pharmacol. 2015 Jul 6;6:136. doi: 10.3389/fphar.2015.00136. eCollection 2015.


Population Pharmacokinetic Model of Sublingual Buprenorphine in Neonatal Abstinence Syndrome.

Ng CM, Dombrowsky E, Lin H, Erlich ME, Moody DE, Barrett JS, Kraft WK.

Pharmacotherapy. 2015 Jul;35(7):670-80. doi: 10.1002/phar.1610. Epub 2015 Jul 14.


Poor predictive value of breath hydrogen response for probiotic effects in IBS.

Yao CK, Barrett JS, Philpott H, Chung AR, van Langenberg D, Garg M, Gibson PR.

J Gastroenterol Hepatol. 2015 Dec;30(12):1731-9. doi: 10.1111/jgh.13015.


Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

van Rongen A, Vaughns JD, Moorthy GS, Barrett JS, Knibbe CA, van den Anker JN.

Br J Clin Pharmacol. 2015 Nov;80(5):1185-96. doi: 10.1111/bcp.12693. Epub 2015 Sep 10.


Drug Dosing and Pharmacokinetics in Children With Obesity: A Systematic Review.

Harskamp-van Ginkel MW, Hill KD, Becker KC, Testoni D, Cohen-Wolkowiez M, Gonzalez D, Barrett JS, Benjamin DK Jr, Siegel DA, Banks P, Watt KM; Best Pharmaceuticals for Children Act–Pediatric Trials Network Administrative Core Committee.

JAMA Pediatr. 2015 Jul;169(7):678-85. doi: 10.1001/jamapediatrics.2015.132. Review. Erratum in: JAMA Pediatr. 2015 Dec;169(12):1179. Becker, Kristian [corrected to Becker, Kristian C].


Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.

Tebas P, Spitsin S, Barrett JS, Tuluc F, Elci O, Korelitz JJ, Wagner W, Winters A, Kim D, Catalano R, Evans DL, Douglas SD.

AIDS. 2015 May 15;29(8):931-9. doi: 10.1097/QAD.0000000000000638.


Challenges and considerations for development of therapeutic proteins in pediatric patients.

Zhang Y, Wei X, Bajaj G, Barrett JS, Meibohm B, Joshi A, Gupta M.

J Clin Pharmacol. 2015 Mar;55 Suppl 3:S103-15. doi: 10.1002/jcph.382. Review.


Malabsorption blood test: Assessing fat absorption in patients with cystic fibrosis and pancreatic insufficiency.

Mascarenhas MR, Mondick J, Barrett JS, Wilson M, Stallings VA, Schall JI.

J Clin Pharmacol. 2015 Aug;55(8):854-65. doi: 10.1002/jcph.484. Epub 2015 Mar 23.


Adjuvant therapies for HIV-associated neurocognitive disorders.

McGuire JL, Barrett JS, Vezina HE, Spitsin S, Douglas SD.

Ann Clin Transl Neurol. 2014 Nov;1(11):938-52. doi: 10.1002/acn3.131. Epub 2014 Oct 23. Review.


Novel method to predict body weight in children based on age and morphological facial features.

Huang Z, Barrett JS, Barrett K, Barrett R, Ng CM.

J Clin Pharmacol. 2015 Apr;55(4):447-51. doi: 10.1002/jcph.422. Epub 2015 Jan 6.


Management Strategies for Abdominal Bloating and Distension.

Foley A, Burgell R, Barrett JS, Gibson PR.

Gastroenterol Hepatol (N Y). 2014 Sep;10(9):561-71.


Predictors of arterial blood pressure control during deliberate hypotension with sodium nitroprusside in children.

Spielberg DR, Barrett JS, Hammer GB, Drover DR, Reece T, Cohane CA, Schulman SR.

Anesth Analg. 2014 Oct;119(4):867-74. doi: 10.1213/ANE.0000000000000376.


Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Barrett JS, Bajaj G, McGuire J, Wu D, Spitsin S, Moorthy G, Zhao X, Tebas P, Evans DL, Douglas SD.

Curr HIV Res. 2014;12(2):121-31.


Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: role in irritable bowel syndrome.

Tuck CJ, Muir JG, Barrett JS, Gibson PR.

Expert Rev Gastroenterol Hepatol. 2014 Sep;8(7):819-34. doi: 10.1586/17474124.2014.917956. Epub 2014 May 15. Review.


Measurement of the survival probabilities for hot fusion reactions.

Yanez R, Loveland W, Yao L, Barrett JS, Zhu S, Back BB, Khoo TL, Alcorta M, Albers M.

Phys Rev Lett. 2014 Apr 18;112(15):152702. Epub 2014 Apr 17.

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