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Items: 1 to 20 of 340

1.

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.

Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA.

J Med Chem. 2019 Oct 14. doi: 10.1021/acs.jmedchem.9b01099. [Epub ahead of print]

PMID:
31566384
2.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126610. doi: 10.1016/j.bmcl.2019.08.014. Epub 2019 Aug 9.

3.

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Camarda G, Jirawatcharadech P, Priestley RS, Saif A, March S, Wong MHL, Leung S, Miller AB, Baker DA, Alano P, Paine MJI, Bhatia SN, O'Neill PM, Ward SA, Biagini GA.

Nat Commun. 2019 Jul 19;10(1):3226. doi: 10.1038/s41467-019-11239-0.

4.

MHC genotyping from rhesus macaque exome sequences.

Caskey JR, Wiseman RW, Karl JA, Baker DA, Lee T, Maddox RJ, Raveendran M, Harris RA, Hu J, Muzny DM, Rogers J, O'Connor DH.

Immunogenetics. 2019 Sep;71(8-9):531-544. doi: 10.1007/s00251-019-01125-w. Epub 2019 Jul 18.

PMID:
31321455
5.

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14164-14173. doi: 10.1073/pnas.1905558116. Epub 2019 Jun 25.

6.

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research.

Mohring F, Hart MN, Rawlinson TA, Henrici R, Charleston JA, Diez Benavente E, Patel A, Hall J, Almond N, Campino S, Clark TG, Sutherland CJ, Baker DA, Draper SJ, Moon RW.

Elife. 2019 Jun 17;8. pii: e45829. doi: 10.7554/eLife.45829.

7.

An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene.

Ravenhall M, Benavente ED, Sutherland CJ, Baker DA, Campino S, Clark TG.

Sci Rep. 2019 Jun 4;9(1):8287. doi: 10.1038/s41598-019-44599-0.

8.

Caregiving for children through conflict and displacement: a pilot study testing the feasibility of delivering and evaluating a light touch parenting intervention for caregivers in the West Bank.

El-Khani A, Maalouf W, Baker DA, Zahra N, Noubani A, Cartwright K.

Int J Psychol. 2019 May 30. doi: 10.1002/ijop.12591. [Epub ahead of print]

PMID:
31144308
9.

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

Patel A, Perrin AJ, Flynn HR, Bisson C, Withers-Martinez C, Treeck M, Flueck C, Nicastro G, Martin SR, Ramos A, Gilberger TW, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 May 10;17(5):e3000264. doi: 10.1371/journal.pbio.3000264. eCollection 2019 May.

10.

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.

Penzo M, de Las Heras-Dueña L, Mata-Cantero L, Diaz-Hernandez B, Vazquez-Muñiz MJ, Ghidelli-Disse S, Drewes G, Fernandez-Alvaro E, Baker DA.

Sci Rep. 2019 May 7;9(1):7005. doi: 10.1038/s41598-019-42801-x.

11.

Metabolomic identification of diagnostic serum-based biomarkers for advanced stage melanoma.

Bayci AWL, Baker DA, Somerset AE, Turkoglu O, Hothem Z, Callahan RE, Mandal R, Han B, Bjorndahl T, Wishart D, Bahado-Singh R, Graham SF, Keidan R.

Metabolomics. 2018 Aug 3;14(8):105. doi: 10.1007/s11306-018-1398-9.

PMID:
30830422
12.

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

Flueck C, Drought LG, Jones A, Patel A, Perrin AJ, Walker EM, Nofal SD, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 Feb 22;17(2):e3000154. doi: 10.1371/journal.pbio.3000154. eCollection 2019 Feb.

13.

Progesterone effects on vaginal cytokines in women with a history of preterm birth.

Garry DJ, Baker DA, Persad MD, Peresleni T, Kocis C, Demishev M.

PLoS One. 2018 Dec 31;13(12):e0209346. doi: 10.1371/journal.pone.0209346. eCollection 2018.

14.

Self-compassion and depression, anxiety, and resilience in adults with epilepsy.

Baker DA, Caswell HL, Eccles FJR.

Epilepsy Behav. 2019 Jan;90:154-161. doi: 10.1016/j.yebeh.2018.11.025. Epub 2018 Dec 14.

PMID:
30557784
15.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):509-514. doi: 10.1016/j.bmcl.2018.11.039. Epub 2018 Nov 20.

16.

Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus.

Buechler C, Semler M, Baker DA, Newman C, Cornish JP, Chavez D, Guerra B, Lanford R, Brasky K, Kuhn JH, Johnson RF, O'Connor DH, Bailey AL.

Viruses. 2018 Dec 10;10(12). pii: E701. doi: 10.3390/v10120701.

17.

Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.

Vranjkovic O, Van Newenhizen EC, Nordness ME, Blacktop JM, Urbanik LA, Mathy JC, McReynolds JR, Miller AM, Doncheck EM, Kloehn TM, Stinnett GS, Gerndt CH, Ketchesin KD, Baker DA, Seasholtz AF, Mantsch JR.

J Neurosci. 2018 Dec 12;38(50):10657-10671. doi: 10.1523/JNEUROSCI.2080-18.2018. Epub 2018 Oct 24.

18.

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.

Benavente ED, Oresegun DR, de Sessions PF, Walker EM, Roper C, Dombrowski JG, de Souza RM, Marinho CRF, Sutherland CJ, Hibberd ML, Mohareb F, Baker DA, Clark TG, Campino S.

Sci Rep. 2018 Oct 18;8(1):15429. doi: 10.1038/s41598-018-33767-3.

19.

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites.

Fang H, Gomes AR, Klages N, Pino P, Maco B, Walker EM, Zenonos ZA, Angrisano F, Baum J, Doerig C, Baker DA, Billker O, Brochet M.

Nat Commun. 2018 Oct 12;9(1):4248. doi: 10.1038/s41467-018-06733-w.

20.

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Tsagris DJ, Birchall K, Bouloc N, Large JM, Merritt A, Smiljanic-Hurley E, Wheldon M, Ansell KH, Kettleborough C, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3168-3173. doi: 10.1016/j.bmcl.2018.08.028. Epub 2018 Aug 27.

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