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Ann Hematol. 2012 Aug;91(8):1161-74. doi: 10.1007/s00277-012-1456-8. Epub 2012 May 26.

Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

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Klinik für Innere Medizin, Hämatologie/Onkologie und Palliativmedizin, Evangelisches Krankenhaus Bielefeld, Schildescher Str. 99, 33611 Bielefeld, Germany.


More than 18,000 autolgous transplantation were performed in Europe in the year 2009. It as a routine procedure in experienced centres. Even if there is a low mortality rate, infections are a major issue after transplantation, occurring in more than 60 % of the patients. In this review we discuss all aspects of infections after autologous stem transplantation, including epidemiology, diagnostics, therapeutic algorithms, prophylaxis and supportive therapy.

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