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Items: 1 to 20 of 173

1.

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ.

Nat Microbiol. 2018 Oct 1. doi: 10.1038/s41564-018-0255-y. [Epub ahead of print]

PMID:
30275511
2.

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.

Cairns AG, Vazquez-Romero A, Mahdi Moein M, Ådén J, Elmore CS, Takano A, Arakawa R, Varrone A, Almqvist F, Schou M.

ACS Chem Neurosci. 2018 Jun 19. doi: 10.1021/acschemneuro.8b00236. [Epub ahead of print]

PMID:
29901990
3.

Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F.

J Med Chem. 2018 May 10;61(9):4165-4175. doi: 10.1021/acs.jmedchem.8b00289. Epub 2018 Apr 27.

PMID:
29667825
4.

Testing Syndromes of Psychopathology in Parent and Youth Ratings Across Societies.

Ivanova MY, Achenbach TM, Rescorla LA, Guo J, Althoff RR, Kan KJ, Almqvist F, Begovac I, Broberg AG, Chahed M, da Rocha MM, Dobrean A, Döepfner M, Erol N, Fombonne E, Fonseca AC, Forns M, Frigerio A, Grietens H, Hewitt-Ramirez N, Juarez F, Kajokienė I, Kanbayashi Y, Kim YA, Larsson B, Leung P, Liu X, Maggiolini A, Minaei A, Moreira PAS, Oh KJ, Petot D, Pisa C, Pomalima R, Roussos A, Rudan V, Sawyer M, Shahini M, Ferreira de Mattos Silvares E, Simsek Z, Steinhausen HC, Szirovicza L, Valverde J, Viola L, Weintraub S, Metzke CW, Wolanczyk T, Woo B, Zhang EY, Zilber N, Žukauskienė R, Verhulst FC.

J Clin Child Adolesc Psychol. 2018 Jan 24:1-14. doi: 10.1080/15374416.2017.1405352. [Epub ahead of print]

PMID:
29364720
5.

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin.

Jain N, Ådén J, Nagamatsu K, Evans ML, Li X, McMichael B, Ivanova MI, Almqvist F, Buxbaum JN, Chapman MR.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12184-12189. doi: 10.1073/pnas.1708805114. Epub 2017 Oct 30.

6.

Thiazolino 2-Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity.

Good JAD, Kulén M, Silver J, Krishnan KS, Bahnan W, Núñez-Otero C, Nilsson I, Wede E, de Groot E, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2017 Nov 22;60(22):9393-9399. doi: 10.1021/acs.jmedchem.7b00716. Epub 2017 Nov 3.

PMID:
29053275
7.

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease.

Pokrzywa M, Pawełek K, Kucia WE, Sarbak S, Chorell E, Almqvist F, Wittung-Stafshede P.

PLoS One. 2017 Sep 1;12(9):e0184117. doi: 10.1371/journal.pone.0184117. eCollection 2017.

8.

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines.

Barange DK, Johnson MT, Cairns AG, Olsson R, Almqvist F.

Org Lett. 2016 Dec 16;18(24):6228-6231. Epub 2016 Nov 28.

PMID:
27978656
9.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.

Hall M, Grundström C, Begum A, Lindberg MJ, Sauer UH, Almqvist F, Johansson J, Sauer-Eriksson AE.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14733-14738. doi: 10.1073/pnas.1614028114. Epub 2016 Dec 5.

10.

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM.

Oncogene. 2016 Dec 1;35(48):6262-6269. doi: 10.1038/onc.2016.158. Epub 2016 May 9.

11.

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.

Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M.

MBio. 2016 Apr 26;7(2):e00221-16. doi: 10.1128/mBio.00221-16.

12.

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Good JA, Andersson C, Hansen S, Wall J, Krishnan KS, Begum A, Grundström C, Niemiec MS, Vaitkevicius K, Chorell E, Wittung-Stafshede P, Sauer UH, Sauer-Eriksson AE, Almqvist F, Johansson J.

Cell Chem Biol. 2016 Mar 17;23(3):404-14. doi: 10.1016/j.chembiol.2016.02.013.

13.

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity.

Good JA, Silver J, Núñez-Otero C, Bahnan W, Krishnan KS, Salin O, Engström P, Svensson R, Artursson P, Gylfe Å, Bergström S, Almqvist F.

J Med Chem. 2016 Mar 10;59(5):2094-108. doi: 10.1021/acs.jmedchem.5b01759. Epub 2016 Feb 22.

PMID:
26849778
14.

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice.

Chermenina M, Chorell E, Pokrzywa M, Antti H, Almqvist F, Strömberg I, Wittung-Stafshede P.

NPJ Parkinsons Dis. 2015 Dec 17;1:15024. doi: 10.1038/npjparkd.2015.24. eCollection 2015.

15.

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation.

Singh P, Chorell E, Krishnan KS, Kindahl T, Åden J, Wittung-Stafshede P, Almqvist F.

Org Lett. 2015 Dec 18;17(24):6194-7. doi: 10.1021/acs.orglett.5b03190. Epub 2015 Dec 9.

PMID:
26650849
16.

Corrigendum: Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Nors Pedersen M, Foderà V, Horvath I, van Maarschalkerweerd A, Nørgaard Toft K, Weise C, Almqvist F, Wolf-Watz M, Wittung-Stafshede P, Vestergaard B.

Sci Rep. 2015 Oct 28;5:15692. doi: 10.1038/srep15692. No abstract available.

17.

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Chorell E, Andersson E, Evans ML, Jain N, Götheson A, Åden J, Chapman MR, Almqvist F, Wittung-Stafshede P.

PLoS One. 2015 Oct 14;10(10):e0140194. doi: 10.1371/journal.pone.0140194. eCollection 2015.

18.

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth.

Nors Perdersen M, Foderà V, Horvath I, van Maarschalkerweerd A, Nørgaard Toft K, Weise C, Almqvist F, Wolf-Watz M, Wittung-Stafshede P, Vestergaard B.

Sci Rep. 2015 May 28;5:10422. doi: 10.1038/srep10422. Erratum in: Sci Rep. 2015;5:15692.

19.

Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication.

Engström P, Bergström M, Alfaro AC, Syam Krishnan K, Bahnan W, Almqvist F, Bergström S.

Int J Med Microbiol. 2015 May;305(3):378-82. doi: 10.1016/j.ijmm.2015.02.007. Epub 2015 Feb 27.

20.

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili.

Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M.

PLoS Pathog. 2015 Mar 4;11(3):e1004697. doi: 10.1371/journal.ppat.1004697. eCollection 2015 Mar.

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