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Items: 1 to 20 of 119

1.

Activation of the cholinergic anti-inflammatory pathway by GTS-21 attenuates cisplatin-induced acute kidney injury in mice.

Chatterjee PK, Yeboah MM, Solanki MH, Kumar G, Xue X, Pavlov VA, Al-Abed Y, Metz CN.

PLoS One. 2017 Nov 30;12(11):e0188797. doi: 10.1371/journal.pone.0188797. eCollection 2017.

2.

Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe-/- mice.

Al-Sharea A, Lee MKS, Whillas A, Flynn MC, Chin-Dusting J, Murphy AJ.

Atherosclerosis. 2017 Oct;265:47-53. doi: 10.1016/j.atherosclerosis.2017.08.010. Epub 2017 Aug 18.

PMID:
28858686
3.

GTS-21 reduces microvascular permeability during experimental endotoxemia.

Schmidt K, Bhakdisongkhram S, Uhle F, Philipsenburg C, Zivkovic AR, Brenner T, Motsch J, Weigand MA, Hofer S.

Microvasc Res. 2018 Jan;115:75-82. doi: 10.1016/j.mvr.2017.08.002. Epub 2017 Aug 15.

PMID:
28818494
4.

Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor.

Tabassum N, Ma Q, Wu G, Jiang T, Yu R.

J Mol Model. 2017 Sep;23(9):251. doi: 10.1007/s00894-017-3419-4. Epub 2017 Aug 2.

PMID:
28770361
5.

Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis.

Zabrodskii PF, Gromov MS, Maslyakov VV.

Bull Exp Biol Med. 2017 Apr;162(6):750-753. doi: 10.1007/s10517-017-3704-3. Epub 2017 Apr 21.

PMID:
28429224
6.

The Role of Erbin in GTS-21 Regulating Inflammtory Responses in MDP-Stimulated Macrophages.

Wu XJ, Yang XM, Song XM, Xu Y, Li JG, Wang YL, Zhang ZZ, Le LL, Liang H, Zhang Y.

Shock. 2017 May;47(5):653-657. doi: 10.1097/SHK.0000000000000785.

PMID:
28410331
7.

An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.

Khan MAS, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JAJ.

Shock. 2017 Aug;48(2):227-235. doi: 10.1097/SHK.0000000000000849.

8.

Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory.

Yang X, Zhao C, Chen X, Jiang L, Su X.

QJM. 2017 Jul 1;110(7):437-445. doi: 10.1093/qjmed/hcx014.

PMID:
28082382
9.

3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats.

Potasiewicz A, Hołuj M, Kos T, Popik P, Arias HR, Nikiforuk A.

Neuropharmacology. 2017 Feb;113(Pt A):188-197. doi: 10.1016/j.neuropharm.2016.10.002. Epub 2016 Oct 4.

PMID:
27717880
10.

Role of α7-Nicotinic Acetylcholine Receptors of B Cells in the Immunotoxic Effect of Organophosphorus Compounds.

Zabrodskii PF, Maslyakov VV, Gromov MS.

Bull Exp Biol Med. 2016 Oct;161(6):779-781. Epub 2016 Oct 26.

PMID:
27783305
11.

Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for α7 Nicotinic Acetylcholine Receptors.

Kashiwagi S, Khan MA, Yasuhara S, Goto T, Kem WR, Tompkins RG, Kaneki M, Martyn JA.

Shock. 2017 Jan;47(1):61-69.

12.

MicroRNA-205‑5b inhibits HMGB1 expression in LPS-induced sepsis.

Zhou W, Wang J, Li Z, Li J, Sang M.

Int J Mol Med. 2016 Jul;38(1):312-8. doi: 10.3892/ijmm.2016.2613. Epub 2016 May 27.

PMID:
27246725
13.

Targeting Functional Biomarkers in Schizophrenia with Neuroimaging.

Wylie KP, Smucny J, Legget KT, Tregellas JR.

Curr Pharm Des. 2016;22(14):2117-23. Review.

14.

EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE.

Nullens S, Staessens M, Peleman C, Schrijvers DM, Malhotra-Kumar S, Francque S, Matteoli G, Boeckxstaens GE, De Man JG, De Winter BY.

Shock. 2016 Apr;45(4):450-9. doi: 10.1097/SHK.0000000000000519.

PMID:
26618987
15.

GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor.

Yue Y, Liu R, Cheng W, Hu Y, Li J, Pan X, Peng J, Zhang P.

Int Immunopharmacol. 2015 Dec;29(2):504-512. doi: 10.1016/j.intimp.2015.10.005. Epub 2015 Oct 18.

PMID:
26490221
16.

Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Potasiewicz A, Kos T, Ravazzini F, Puia G, Arias HR, Popik P, Nikiforuk A.

Br J Pharmacol. 2015 Nov;172(21):5123-35. doi: 10.1111/bph.13277. Epub 2015 Oct 10. Erratum in: Br J Pharmacol. 2016 Jan;173(2):411.

18.

Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats.

Kong FJ, Ma LL, Zhang HH, Zhou JQ.

J Surg Res. 2015 Mar;194(1):255-61. doi: 10.1016/j.jss.2014.09.043. Epub 2014 Oct 5.

PMID:
25450597
19.

Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancy.

Wong DF, Kuwabara H, Pomper M, Holt DP, Brasic JR, George N, Frolov B, Willis W, Gao Y, Valentine H, Nandi A, Gapasin L, Dannals RF, Horti AG.

Mol Imaging Biol. 2014 Oct;16(5):730-8. doi: 10.1007/s11307-014-0779-3.

20.

Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21.

Hu Y, Liu R, Li J, Yue Y, Cheng W, Zhang P.

Biomed Res Int. 2014;2014:325875. doi: 10.1155/2014/325875. Epub 2014 Feb 27.

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