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Sci Rep. 2019 Aug 21;9(1):12207. doi: 10.1038/s41598-019-48226-w.

Specimen Collection for Translational Studies in Hidradenitis Suppurativa.

Author information

1
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. angel_byrd@alumni.brown.edu.
2
Department of Dermatology, Howard University College of Medicine, Washington, DC, 20060, USA. angel_byrd@alumni.brown.edu.
3
Meharry Medical College, Nashville, TN, 37208, USA.
4
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
5
University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
6
Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
7
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
8
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
9
Departments of Dermatology and Epidemiology, Columbia University, New York, NY, 10032, USA.
10
Program for Clinical Research, Department of Dermatology, University of California San Francisco, San Francisco, CA, 94143-0808, USA.
11
Stanford University School of Medicine, Stanford, CA, 94305, USA.
12
Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, 10065, USA.
13
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
14
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
15
Department of Dermatology, Liverpool Hospital, Sydney, NSW, 2170, Australia.
16
Ingham Institute of Applied Medical Research, Liverpool, Sydney, NSW, 2170, Australia.
17
University of New South Wales, Sydney, NSW, 2033, Australia.
18
Department of Medicine (Dermatology), University of Toronto, Toronto, Ontario, M1C 1A4, Canada.
19
Division of Dermatology, Women's College Hospital, Toronto, ON, M5S 1B2, Canada.
20
The Rockefeller University, New York, NY, 10065, USA.
21
Department of Dermatology, Howard University College of Medicine, Washington, DC, 20060, USA.

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053-4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is  retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.

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