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Items: 11

1.

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.

Csanády L, Vergani P, Gadsby DC.

Physiol Rev. 2019 Jan 1;99(1):707-738. doi: 10.1152/physrev.00007.2018. Review.

PMID:
30516439
2.

The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR.

Brennan SC, Wilkinson WJ, Tseng HE, Finney B, Monk B, Dibble H, Quilliam S, Warburton D, Galietta LJ, Kemp PJ, Riccardi D.

Sci Rep. 2016 Feb 25;6:21975. doi: 10.1038/srep21975.

3.

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL.

Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889.

4.

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.

Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL.

Mol Biol Cell. 2012 Nov;23(21):4188-202. doi: 10.1091/mbc.E12-06-0424. Epub 2012 Sep 12.

5.

Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.

Zhou JJ, Li MS, Qi J, Linsdell P.

J Gen Physiol. 2010 Mar;135(3):229-45. doi: 10.1085/jgp.200910327. Epub 2010 Feb 8.

6.

Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.

Hwang TC, Sheppard DN.

J Physiol. 2009 May 15;587(Pt 10):2151-61. doi: 10.1113/jphysiol.2009.171595. Epub 2009 Mar 30. Review.

7.

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.

Seavilleklein G, Amer N, Evagelidis A, Chappe F, Irvine T, Hanrahan JW, Chappe V.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1366-75. doi: 10.1152/ajpcell.00034.2008. Epub 2008 Sep 17.

8.

Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.

Aleksandrov L, Mengos A, Chang X, Aleksandrov A, Riordan JR.

J Biol Chem. 2001 Apr 20;276(16):12918-23. Epub 2001 Jan 29.

9.

R-domain interactions with distal regions of CFTR lead to phosphorylation and activation.

King SA, Sorscher EJ.

Biochemistry. 2000 Aug 15;39(32):9868-75.

PMID:
10933805
10.

FLAG epitope positioned in an external loop preserves normal biophysical properties of CFTR.

Schultz BD, Takahashi A, Liu C, Frizzell RA, Howard M.

Am J Physiol. 1997 Dec;273(6 Pt 1):C2080-9.

PMID:
9435515

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