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Dev Cell. 2011 Jun 14;20(6):733-4. doi: 10.1016/j.devcel.2011.05.017.

Moving right along: how PP1 helps clear the checkpoint.

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Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA.


Spindle checkpoint silencing is crucial for cell-cycle progression, but mechanisms underlying this process remain mysterious. Two papers, one in this issue of Developmental Cell (Meadows et al., 2011) and one in Current Biology (Rosenberg et al., 2011), begin to show how phosphatase PP1-gamma connects chromosome-microtubule attachment with anaphase entry.

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