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Cell. 2013 Aug 15;154(4):716-8. doi: 10.1016/j.cell.2013.07.043.

Bumping up kinase activity with an ATP-derived neo-substrate.

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1
Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA. rkleiner@rockefeller.edu

Abstract

Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.

PMID:
23953104
DOI:
10.1016/j.cell.2013.07.043
[Indexed for MEDLINE]
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