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Antimicrob Agents Chemother. 2014 Oct;58(10):6297-301. doi: 10.1128/AAC.02784-14. Epub 2014 Aug 4.

Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis.

Author information

1
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China zhangwenhong@fudan.edu.cn.
2
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
3
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recovery, a higher cerebrospinal fluid (CSF)/blood glucose ratio, and lower CSF white blood cell counts than did the BR group. Short-term linezolid supplementation may be a more effective treatment for life-threatening TBM.

PMID:
25092692
PMCID:
PMC4187991
DOI:
10.1128/AAC.02784-14
[Indexed for MEDLINE]
Free PMC Article

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