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Pediatrics. 2012 Oct;130(4):738-44. doi: 10.1542/peds.2012-0194. Epub 2012 Sep 3.

A framework for elimination of perinatal transmission of HIV in the United States.

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  • 1Centers for Disease Control and Prevention, MS E-45, 1600 Clifton Rd, Atlanta, GA 30333, USA.


The availability of effective interventions to prevent mother-to-child HIV transmission and the significant reduction in the number of HIV-infected infants in the United States have led to the concept that elimination of mother-to-child HIV transmission (EMCT) is possible. Goals for elimination are presented. We also present a framework by which elimination efforts can be coordinated, beginning with comprehensive reproductive health care (including HIV testing) and real-time case-finding of pregnancies in HIV-infected women, and conducted through the following: facilitation of comprehensive clinical care and social services for women and infants; case review and community action; allowing continuous quality research in prevention and long-term follow-up of HIV-exposed infants; and thorough data reporting for HIV surveillance and EMCT evaluation. It is emphasized that EMCT will not be a one-time accomplishment but, rather, will require sustained effort as long as there are new HIV infections in women of childbearing age.

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