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Items: 1 to 20 of 33

1.

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F.

Nature. 1998 Jan 22;391(6665):387-90.

PMID:
9450754
2.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
3.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
4.

The function of presenilin-1 in amyloid beta-peptide generation and brain development.

Saftig P, Hartmann D, De Strooper B.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):271-9. Review.

PMID:
10653282
5.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
6.

Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing.

Borchelt DR.

Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S15-8. Review.

PMID:
9562461
7.

Protein trafficking and Alzheimer's disease.

Uemura K, Kuzuya A, Shimohama S.

Curr Alzheimer Res. 2004 Feb;1(1):1-10. Review.

PMID:
15975080
9.

Amyloid beta/A4 precursor protein (APP) processing in lysosomes.

Tagawa K, Maruyama K, Ishiura S.

Ann N Y Acad Sci. 1992 Dec 31;674:129-37. Review.

PMID:
1288358
10.

[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease].

Iwatsubo T.

Nihon Yakurigaku Zasshi. 2002 Nov;120(1):30P-33P. Review. Japanese.

PMID:
12491772
11.
12.

The role of extracellular matrix in the processing of the amyloid protein precursor of Alzheimer's disease.

Small DH, Nurcombe V, Clarris H, Beyreuther K, Masters CL.

Ann N Y Acad Sci. 1993 Sep 24;695:169-74. Review.

PMID:
8239278
13.

[Molecular cell biology of presenilins].

Tomita T, Iwatsubo T.

Nihon Yakurigaku Zasshi. 1999 Dec;114(6):337-46. Review. Japanese.

PMID:
10672594
14.

Identification of the role of presenilins beyond Alzheimer's disease.

Thinakaran G, Parent AT.

Pharmacol Res. 2004 Oct;50(4):411-8. Review.

PMID:
15304238
15.

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

Selkoe D, Kopan R.

Annu Rev Neurosci. 2003;26:565-97. Epub 2003 Apr 18. Review.

PMID:
12730322
16.

The role of proteolysis in Alzheimer's disease.

Hooper NM, Trew AJ, Parkin ET, Turner AJ.

Adv Exp Med Biol. 2000;477:379-90. Review.

PMID:
10849764
17.

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.

Lichtenthaler SF, Haass C, Steiner H.

J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14. Review.

18.

The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes.

Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P.

Neurobiol Aging. 1992 Sep-Oct;13(5):601-3. Review.

PMID:
1461349
19.

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.

Prox J, Rittger A, Saftig P.

Exp Brain Res. 2012 Apr;217(3-4):331-41. doi: 10.1007/s00221-011-2952-0. Epub 2011 Nov 27. Review.

PMID:
22120156

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