Format

Send to

Choose Destination

Links from PubMed

Fertil Steril. 1997 Dec;68(6):981-6.

Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial.

Author information

1
Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Oakland, California, USA.

Abstract

OBJECTIVE:

To evaluate possible estrogenic effects of dong quai on vaginal cells and on endometrial thickness in postmenopausal women.

DESIGN:

Double-blind, randomized, placebo-controlled clinical trial.

SETTING:

Department of Obstetrics and Gynecology in a large health maintenance organization (HMO).

PATIENT(S):

Seventy-one postmenopausal women (mean age [+/- SD], 52.4 +/- 6 years) who had follicle-stimulating hormone levels (third-generation assay) of > 30 mIU/mL with hot flashes.

INTERVENTION(S):

Subjects were randomized to treatment with either dong quai or placebo for 24 weeks.

MAIN OUTCOME MEASURE(S):

Endometrial thickness was measured by transvaginal ultrasonography; vaginal cells were evaluated for cellular maturation; menopausal symptoms were evaluated by reviewing the Kupperman index and the diary of vasomotor flushes.

RESULT(S):

We observed no statistically significant differences between groups in endometrial thickness, in vaginal maturation index, in number of vasomotor flushes, or in the Kupperman index.

CONCLUSION(S):

Used alone, dong quai does not produce estrogen-like responses in endometrial thickness or in vaginal maturation and was no more helpful than placebo in relieving menopausal symptoms.

PMID:
9418683
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center