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Clin Exp Obstet Gynecol. 2012;39(4):509-11.

Determining the optimal fentanyl dose for dilation and curettage procedures.

Author information

1
Department of Anesthesiology and Reanimation, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey. drmustafaogurlu@yahoo.com

Abstract

AIM:

This study attempted to determine an optimal dose of fentanyl, a drug frequently used in dilation and curettage (D&C) procedures, which is commonly performed as a brief outpatient intervention.

METHODS:

The optimal fentanyl dose was determined using Dixon's up-and-down method. The study was accomplished with a beginning fentanyl dose of 1 microg kg(-1) with a step size of 0.1 microg kg(-1) fentanyl.

RESULTS:

The ED50 [95% confidence interval (CI)] for fentanyl for successful anesthesia in D&C procedures was found to be 0.45 (0.35-0.55) microg kg(-1) and the ED95 value was 0.50 (0.45-0.60) microg kg(-1).

CONCLUSION:

This dose is considerably lower than the standard dose that is used at present, which is 1 microg kg(-1). To the best of our knowledge, the current study is the first to show that a significantly reduced dose of fentanyl can be as effective as higher doses in D&C procedures using Dixon's up-and-down method.

PMID:
23444755
[Indexed for MEDLINE]
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