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Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics.

Tsuji BT, Harigaya Y, Lesse AJ, Forrest A, Ngo D.

J Chemother. 2013 Feb;25(1):32-5. doi: 10.1179/1973947812Y.0000000060.


Is there any rationale for treatment of Staphylococcus aureus infections with antimicrobials that are determined to be ineffective in vitro?

Uek├Âtter A, Peters G, Becker K.

Clin Microbiol Infect. 2011 Aug;17(8):1142-7. doi: 10.1111/j.1469-0691.2011.03549.x. Epub 2011 Jun 14. Review.

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