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Obesity (Silver Spring). 2013 Mar;21(3):441-8. doi: 10.1002/oby.20052.

The effects of weight loss on relative bone mineral density in premenopausal women.

Author information

  • 1Department of Human Studies, University of Alabama-Birmingham, Birmingham, AL, USA. khamilton1@crimson.ua.edu

Abstract

OBJECTIVE:

This study compared BMD relative to body weight following a ∼6-month weight loss program and a 1-year weight maintenance phase in premenopausal women and determined whether African American (AA) and European-American (EA) women's BMD respond similarly during weight loss.

DESIGN AND METHODS:

Premenopausal women (n = 115, 34 ± 5 years) were evaluated in an overweight state (BMI between 27 and 30 kg/m(2) ), following an 800 kcal/day diet/exercise program designed to reduce BMI<25 kg/m(2) , and 1-year following weight loss.

RESULTS:

BMD relative to body weight (Z-scores) increased after weight loss, but decreased during the 1-year weight maintenance phase. All 1-year follow-up BMD Z-scores were increased (except L1) compared to baseline measurements (P < 0.05). These sites included the hip neck (+0.088, P = 0.014), total hip (+0.099, P = 0.001), L2 (+0.127, P = 0.013), L3 (+0.135, P = 0.014), and L4 (+0.199, P = 0.002). AAs had significantly higher absolute BMD at all sites (P < 0.05) compared to EAs, but no time by race interactions were evident during weight loss (except in L3).

CONCLUSION:

These results may indicate that weight loss is safe with regard to bone health for overweight premenopausal women.

PMID:
23404937
PMCID:
PMC3630243
DOI:
10.1002/oby.20052
[PubMed - indexed for MEDLINE]
Free PMC Article
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