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Items: 1 to 20 of 63

1.

HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.

Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M.

Chem Biol. 2013 Jan 24;20(1):19-33. doi: 10.1016/j.chembiol.2012.10.015.

2.

High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Wu B, Barile E, De SK, Wei J, Purves A, Pellecchia M.

Curr Top Med Chem. 2015;15(20):2032-42. Review.

3.

Design of small molecule libraries for NMR screening and other applications in drug discovery.

Jacoby E, Davies J, Blommers MJ.

Curr Top Med Chem. 2003;3(1):11-23. Review.

PMID:
12570776
4.

Fragment-based drug design: computational & experimental state of the art.

Hoffer L, Renaud JP, Horvath D.

Comb Chem High Throughput Screen. 2011 Jul;14(6):500-20. Review.

PMID:
21521152
5.

Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.

López-Vallejo F, Caulfield T, Martínez-Mayorga K, Giulianotti MA, Nefzi A, Houghten RA, Medina-Franco JL.

Comb Chem High Throughput Screen. 2011 Jul;14(6):475-87. Review.

PMID:
21521151
6.

Library design for fragment based screening.

Schuffenhauer A, Ruedisser S, Marzinzik AL, Jahnke W, Blommers M, Selzer P, Jacoby E.

Curr Top Med Chem. 2005;5(8):751-62. Review.

PMID:
16101415
7.

NMR-based screening methods for lead discovery.

Vogtherr M, Fiebig K.

EXS. 2003;(93):183-202. Review.

PMID:
12613177
8.

Process of Fragment-Based Lead Discovery-A Perspective from NMR.

Ma R, Wang P, Wu J, Ruan K.

Molecules. 2016 Jul 16;21(7). pii: E854. doi: 10.3390/molecules21070854. Review.

9.

Fragment-based drug discovery using rational design.

Jhoti H.

Ernst Schering Found Symp Proc. 2007;(3):169-85. Review.

PMID:
18510103
10.

High impact technologies for natural products screening.

Koehn FE.

Prog Drug Res. 2008;65:175, 177-210. Review.

PMID:
18084916
11.

From fragment screening to potent binders: strategies for fragment-to-lead evolution.

Eitner K, Koch U.

Mini Rev Med Chem. 2009 Jul;9(8):956-61. Review.

PMID:
19601891
12.

Increasing the delivery of next generation therapeutics from high throughput screening libraries.

Wigglesworth MJ, Murray DC, Blackett CJ, Kossenjans M, Nissink JW.

Curr Opin Chem Biol. 2015 Jun;26:104-10. doi: 10.1016/j.cbpa.2015.04.006. Epub 2015 Apr 20. Review.

PMID:
25909818
13.

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

Albert JS, Blomberg N, Breeze AL, Brown AJ, Burrows JN, Edwards PD, Folmer RH, Geschwindner S, Griffen EJ, Kenny PW, Nowak T, Olsson LL, Sanganee H, Shapiro AB.

Curr Top Med Chem. 2007;7(16):1600-29. Review.

PMID:
17979771
14.

Recent progress in fragment-based lead discovery.

Schulz MN, Hubbard RE.

Curr Opin Pharmacol. 2009 Oct;9(5):615-21. doi: 10.1016/j.coph.2009.04.009. Epub 2009 May 27. Review.

PMID:
19477685
15.

The synergy between combinatorial chemistry and high-throughput screening.

Diller DJ.

Curr Opin Drug Discov Devel. 2008 May;11(3):346-55. Review.

PMID:
18428088
16.

Combining biophysical screening and X-ray crystallography for fragment-based drug discovery.

Hennig M, Ruf A, Huber W.

Top Curr Chem. 2012;317:115-43. doi: 10.1007/128_2011_225. Review.

PMID:
21837555
17.

Liquid-phase combinatorial library synthesis: recent advances and future perspectives.

Barot KP, Nikolova S, Ivanov I, Ghate MD.

Comb Chem High Throughput Screen. 2014;17(5):417-38. Review.

PMID:
24237348
18.

Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.

Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW.

Top Curr Chem. 2012;317:83-114. doi: 10.1007/128_2011_183. Review.

PMID:
21647837
19.

Molecular complexity and fragment-based drug discovery: ten years on.

Leach AR, Hann MM.

Curr Opin Chem Biol. 2011 Aug;15(4):489-96. doi: 10.1016/j.cbpa.2011.05.008. Epub 2011 Jun 12. Review.

PMID:
21665521
20.

Fragment-based lead discovery and design.

Joseph-McCarthy D, Campbell AJ, Kern G, Moustakas D.

J Chem Inf Model. 2014 Mar 24;54(3):693-704. doi: 10.1021/ci400731w. Epub 2014 Feb 19. Review.

PMID:
24490951

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