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Retin Cases Brief Rep. 2010 Summer;4(3):233-9. doi: 10.1097/ICB.0b013e3181ae71ca.

Maculopathy diagnosed with high-resolution fourier-domain optical coherence tomography in eyes with previously unexplained visual loss.

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1
Department of Ophthalmology & Vision Science, University of California Davis Medical Center, Sacramento, California.

Abstract

PURPOSE:

To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss.

METHODS:

Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourier-domain optical coherence tomography instrument with axial resolution of 4 μm to 4.5 μm and transverse resolution of 10 μm to 15 μm.

RESULTS:

Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourier-domain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen.

CONCLUSION:

Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.

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