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Mov Disord. 2012 Sep 1;27(10):1304-7. doi: 10.1002/mds.25123. Epub 2012 Aug 1.

Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation.

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  • 1Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada. lilinaz.hazrati@utoronto.ca

Abstract

BACKGROUND:

Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP).

METHODS:

Two patients with PSP underwent unilateral PPN-DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location.

RESULTS:

Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN.

CONCLUSIONS:

We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes.

Copyright © 2012 Movement Disorder Society.

[PubMed - indexed for MEDLINE]
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