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Items: 1 to 20 of 82

1.

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Carragher NO, Brunton VG, Frame MC.

Drug Discov Today. 2012 Mar;17(5-6):203-14. Review.

PMID:
22493783
2.

Advancing cancer drug discovery towards more agile development of targeted combination therapies.

Carragher NO, Unciti-Broceta A, Cameron DA.

Future Med Chem. 2012 Jan;4(1):87-105. doi: 10.4155/fmc.11.169. Review.

PMID:
22168166
3.

Integrative oncoproteomics strategies for anticancer drug discovery.

Liu R, Wang K, Yuan K, Wei Y, Huang C.

Expert Rev Proteomics. 2010 Jun;7(3):411-29. doi: 10.1586/epr.10.14. Review.

PMID:
20536311
4.

Adopting network pharmacology for cancer drug discovery.

Azmi AS.

Curr Drug Discov Technol. 2013 Jun;10(2):95-105. Review.

PMID:
23237672
5.

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

Emoto C, Murayama N, Rostami-Hodjegan A, Yamazaki H.

Curr Drug Metab. 2010 Oct;11(8):678-85. Review.

PMID:
20973757
6.

Stratified medicine for cancer therapy.

Shaw EC, Johnson PW.

Drug Discov Today. 2012 Mar;17(5-6):261-8. Review.

PMID:
22493785
7.

Targeting survivin in cancer: the cell-signalling perspective.

Kanwar JR, Kamalapuram SK, Kanwar RK.

Drug Discov Today. 2011 Jun;16(11-12):485-94. doi: 10.1016/j.drudis.2011.04.001. Epub 2011 Apr 12. Review.

PMID:
21511051
8.

Improving drug discovery with contextual assays and cellular systems analysis.

Westwick JK, Lamerdin JE.

Methods Mol Biol. 2011;756:61-73. doi: 10.1007/978-1-61779-160-4_3. Review.

PMID:
21870220
9.

Identification of disease-relevant genes for molecularly-targeted drug discovery.

Kauselmann G, Dopazo A, Link W.

Curr Cancer Drug Targets. 2012 Jan;12(1):1-13. Review.

PMID:
22165964
10.

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth.

Gibbons JJ, Abraham RT, Yu K.

Semin Oncol. 2009 Dec;36 Suppl 3:S3-S17. doi: 10.1053/j.seminoncol.2009.10.011. Review.

PMID:
19963098
11.

The Hedgehog pathway as a drug target in cancer therapy.

Lauth M, Toftgård R.

Curr Opin Investig Drugs. 2007 Jun;8(6):457-61. Review.

PMID:
17621875
12.

New avenues to target Wnt/β-catenin signaling.

Verkaar F, Zaman GJ.

Drug Discov Today. 2011 Jan;16(1-2):35-41. doi: 10.1016/j.drudis.2010.11.007. Epub 2010 Nov 24. Review.

PMID:
21111060
13.

The opportunities and challenges of personalized genome-based molecular therapies for cancer: targets, technologies, and molecular chaperones.

Workman P.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S45-56. Epub 2003 Jun 18. Review.

PMID:
12819933
14.

Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.

Shapira A, Livney YD, Broxterman HJ, Assaraf YG.

Drug Resist Updat. 2011 Jun;14(3):150-63. doi: 10.1016/j.drup.2011.01.003. Epub 2011 Feb 16. Review.

PMID:
21330184
15.

Has molecular and cellular imaging enhanced drug discovery and drug development?

Niu G, Chen X.

Drugs R D. 2008;9(6):351-68. doi: 10.2165/0126839-200809060-00002. Review.

PMID:
18989988
16.

Cancer stem cells as the relevant biomass for drug discovery.

Winquist RJ, Furey BF, Boucher DM.

Curr Opin Pharmacol. 2010 Aug;10(4):385-90. doi: 10.1016/j.coph.2010.06.008. Epub 2010 Jul 12. Review.

PMID:
20630801
17.

Emerging strategies to strengthen the anti-tumour activity of type I interferons: overcoming survival pathways.

Caraglia M, Marra M, Tagliaferri P, Lamberts SW, Zappavigna S, Misso G, Cavagnini F, Facchini G, Abbruzzese A, Hofland LJ, Vitale G.

Curr Cancer Drug Targets. 2009 Aug;9(5):690-704. Epub 2009 Aug 1. Review.

PMID:
19508175
18.

Molecular imaging with bioconjugates in mouse models of cancer.

Mather S.

Bioconjug Chem. 2009 Apr;20(4):631-43. doi: 10.1021/bc800401x. Review.

PMID:
19086866
19.

Targeting PI3K-AKT pathway for cancer therapy.

Lu Y, Wang H, Mills GB.

Rev Clin Exp Hematol. 2003 Jun;7(2):205-28. Review.

PMID:
14763163
20.

Mechanisms of drug inhibition of signalling molecules.

Sebolt-Leopold JS, English JM.

Nature. 2006 May 25;441(7092):457-62. Review.

PMID:
16724058

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