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Ophthalmic Surg Lasers Imaging. 2012 Mar-Apr;43(2):97-108. doi: 10.3928/15428877-20111222-02. Epub 2012 Jan 3.

Reproducibility of macular thickness measurement among five OCT instruments: effects of image resolution, image registration, and eye tracking.

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  • 1Department of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, California 95817, USA.



To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments.


Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration.


All instruments had superior rCMT in normal versus pathologic eyes (P < .001). No difference in rCMT was noted among instruments in normal eyes (P = .92), but TD-OCT was superior to SD-OCT (P = .017) in pathologic eyes. Cirrus image registration improved rCMT for normal eyes (P = .04), with borderline improvement in pathologic eyes (P = .06). Spectralis eye tracking improved rCMT in normal (P = .01) and pathologic (P = .004) eyes.


Higher image resolution with SD-OCT may not improve rCMT, but image registration and eye tracking options may improve rCMT.

Copyright 2012, SLACK Incorporated.

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