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Items: 9

1.

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.

Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J.

Mol Cell. 2011 Dec 23;44(6):864-77. doi: 10.1016/j.molcel.2011.10.015.

2.

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.

Saunier E, Benelli C, Bortoli S.

Int J Cancer. 2016 Feb 15;138(4):809-17. doi: 10.1002/ijc.29564. Epub 2015 Apr 28. Review.

3.

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells.

Smolková K, Plecitá-Hlavatá L, Bellance N, Benard G, Rossignol R, Ježek P.

Int J Biochem Cell Biol. 2011 Jul;43(7):950-68. doi: 10.1016/j.biocel.2010.05.003. Epub 2010 May 10. Review.

PMID:
20460169
4.

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

Zhang W, Zhang SL, Hu X, Tam KY.

Int J Biol Sci. 2015 Nov 1;11(12):1390-400. doi: 10.7150/ijbs.13325. eCollection 2015. Review.

5.
6.

Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.

Sugden MC, Holness MJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):151-65. Review.

PMID:
12476789
7.

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.

Mazurek S.

Int J Biochem Cell Biol. 2011 Jul;43(7):969-80. doi: 10.1016/j.biocel.2010.02.005. Epub 2010 Feb 13. Review.

PMID:
20156581
8.

Emerging metabolic targets in cancer therapy.

Zhao Y, Liu H, Riker AI, Fodstad O, Ledoux SP, Wilson GL, Tan M.

Front Biosci (Landmark Ed). 2011 Jan 1;16:1844-60. Review.

9.

Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning.

Semenza GL.

Biochim Biophys Acta. 2011 Jul;1813(7):1263-8. doi: 10.1016/j.bbamcr.2010.08.006. Epub 2010 Aug 21. Review.

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